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IFNG — SEC14L2

Text-mined interactions from Literome

Qin et al., Cancer Res 2002 (Neoplasms, Experimental) : In mixed tumor/lymphocyte culture, TAP1 expression by tumor cells significantly increased the IFN-gamma production of antigen-specific spleen cells from immunized, but not from naive, mice
Juffs et al., Pathology 2004 (Leukemia, Lymphocytic, Chronic, B-Cell) : B-CLL cells upregulated TAP protein expression in response to IFN-gamma
Belicha-Villanueva et al., Immunology 2008 (Melanoma) : Interferon-gamma induces both TAP and tapasin so dissection of which protein contributes more to HLA class I expression has not been possible previously ... Interferon-gamma increases TAP protein levels dramatically but HLA class I expression at the cell surface does not increase substantially, indicating that a large increase in peptide supply is not sufficient to increase HLA class I expression
Dumont et al., Eur J Immunol 1987 : The effect of IFN-gamma on Ly-6A/E and TAP expression reached a maximum with as little as 10 U/ml and required only 18-24 h of incubation
Ma et al., J Biol Chem 1997 : The kinetics of interferon (IFN)-gamma induction of TAP , peptide transport capacity, and HLA class I molecule expression was determined in endothelial cells, which are targets of CTL following transplantation or viral infection ... Peptide transport capacity in endothelial and HeLa cells increases within 6 h of IFN-gamma treatment, suggesting that the IFN-gamma induced TAP heterodimers are functional ... Therefore, the IFN-gamma induced increase in TAP proteins is accompanied by an increased peptide transport capacity, which may be important in supporting the subsequent rise in HLA class I protein expression
al-Yaman et al., Trans R Soc Trop Med Hyg 1997 (Fever...) : Analyses of the relation of T cell response to malaria infection showed that the IFN gamma response to SPf66 was positively correlated with parasite density ( r = 0.27, P = 0.001 )
Seliger et al., Clin Cancer Res 1997 (Carcinoma, Renal Cell...) : Here, we show that IFN-gamma stimulation of human renal cell carcinoma lines increased the MHC class I, transporter associated with antigen processing ( TAP ), and LMP transcript and protein levels, but TAP and LMP expression are more rapidly induced by IFN-gamma than MHC class I molecules