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CDKN1A — SFN

Text-mined interactions from Literome

Parnaud et al., Nutr Cancer 2004 : In the present study, our results show that SFN induced p21 expression
Shen et al., Cancer Chemother Pharmacol 2006 : At high doses ( > 25 microM ), SFN dramatically induces the expression of p21 ( CIP1 ) while significantly inhibits the expression of the G ( 1 ) phase cell cycle regulatory genes such as cyclin D1, cyclin A, and c-myc ... Furthermore, the activation of the ERK and p38 pathways by SFN is involved in the upregulation of p21 ( CIP1 ) and cyclin D1, whereas the activation of the JNK pathway plays a contradictory role and may be partially involved in the downregulation of cyclin D1
Matsui et al., Oncol Rep 2007 (Bone Neoplasms...) : SFN induced the expression of p21 ( WAF1/CIP1 ) protein causing the cell cycle arrest in a dose dependent manner ... We showed that SFN induced the growth arrest and up-regulated the expression of p21 ( WAF1/CIP1 ) protein in a p53 independent manner in human osteosarcoma MG63 cells ... Furthermore, SFN is a potent inducer of p21 ( WAF1/CIP1 ) in osteosarcoma cells
Kim et al., Journal of clinical biochemistry and nutrition 2010 : In addition, SFN increased the p21 promoter activity significantly ... Furthermore, SFN induced p21 protein expression in a nude mouse xenograft model suggesting that SFN is a potent inducer of the p21 protein in human oral squamous carcinoma cells
Roy et al., Journal of molecular signaling 2010 : SFN induced the expression of p21/CIP1 and p27/KIP1, and inhibited the expression of cyclin D1
Clarke et al., Mol Nutr Food Res 2011 (Hyperplasia...) : SFN treatment also selectively decreased HDAC activity, and Class I and II HDAC proteins, increased acetylated histone H3 at the promoter for P21, induced p21 expression and increased tubulin acetylation in prostate cancer cells