◀ Back to SYK

SHC1 — SYK

Pathways - manually collected, often from reviews:

• BioCarta il 2 signaling pathway: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• KEGG Natural killer cell mediated cytotoxicity: SYK → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• Reactome Reaction: SYK → SHC1 (indirect_complex) Brooks et al., J Immunol 2000, Marshall et al., J Exp Med 2000, Fujimoto et al., Immunity 2000, Baba et al., Proc Natl Acad Sci U S A 2001, Rodriguez et al., J Biol Chem 2001, Chiu et al., EMBO J 2002, Xu et al., J Immunol 2002, Coggeshall et al., Proc Natl Acad Sci U S A 1992, Sekiya et al., J Biol Chem 2004, Brooks et al., J Immunol 2004, Roifman et al., Biochem Biophys Res Commun 1992, Kim et al., Mol Cell Biol 2004, Carter et al., Proc Natl Acad Sci U S A 1991, Weng et al., J Biol Chem 1994, Roifman et al., Biochem Biophys Res Commun 1993, Chalupny et al., EMBO J 1993, Uckun et al., J Biol Chem 1993, de Weers et al., J Biol Chem 1994, Saxton et al., J Immunol 1994, Smit et al., J Biol Chem 1996, Kuwahara et al., Int Immunol 1996, Harmer et al., Mol Cell Biol 1997, Fu et al., J Biol Chem 1997, Bae et al., J Biol Chem 1998, Fu et al., Immunity 1998
• Reactome Reaction: SYK → SHC1 (reaction) Gross et al., J Biol Chem 1999, Lennartsson et al., Oncogene 1999, Nore et al., Biochim Biophys Acta 2003, Humphries et al., J Biol Chem 2004, Reeve et al., J Immunol 2009, Ormsby et al., Blood 2011, Kawakami et al., Mol Cell Biol 1994, Rawlings et al., Science 1996, Park et al., Immunity 1996, Jabril-Cuenod et al., J Biol Chem 1996, Bubeck Wardenburg et al., J Biol Chem 1996, Deckert et al., Immunity 1996, Hendricks-Taylor et al., J Biol Chem 1997, Harmer et al., Mol Cell Biol 1997

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: SHC1 — SYK (in vivo) Marchetto et al., Leukemia 1999*, Yamaguchi et al., Leukemia 1997*, Sato et al., Biochem Biophys Res Commun 1997*, Walk et al., Eur J Immunol 1998

Text-mined interactions from Literome

Jabril-Cuenod et al., J Biol Chem 1996 : Syk dependent phosphorylation of Shc ... Therefore, the Syk dependent tyrosine phosphorylation of Shc and its association with Grb2 may provide a pathway through Sos for activation of Ras by FcepsilonRI
Walk et al., Eur J Immunol 1998 : Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR mediated phosphorylation of the adapter protein Shc