Gene interactions and pathways from curated databases and text-mining

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FOXO3 — SIRT1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Nemoto et al., Science 2004 (Starvation) : Stimulation of SIRT1 transcription by Foxo3a was mediated through two p53 binding sites present in the SIRT1 promoter, and a nutrient-sensitive physical interaction was observed between Foxo3a and p53
Oh et al., Mol Pharmacol 2010 : Overexpression of SIRT1 enhanced both FoxO reporter activity and nuclear levels of FoxO1
Xiong et al., J Biol Chem 2011 : Consistently, FoxO1 overexpression increases SIRT1 expression, and FoxO1 depletion by siRNA reduces SIRT1 expression at both the messenger RNA and protein levels in vascular smooth muscle cells and HEK293 cells
Rizki et al., PLoS Genet 2011 : The conserved DAF-16/FOXO transcription factors and SIR-2.1/SIRT1 deacetylases are critical for diverse biological processes, particularly longevity and stress response ; and complex regulation of DAF-16/FOXO by SIR-2.1/SIRT1 is central to appropriate biological outcomes
Parker et al., J Neurosci 2012 : In Caenorhabditis elegans, sir-2.1/SIRT1 overexpression protects neurons from the early phases of expanded polyglutamine ( polyQ ) toxicity, and this protection requires the longevity promoting factor daf-16/FOXO
Kok et al., Arthritis Rheum 2013 (Arthritis, Experimental...) : To examine the role of sirtuin-1 (SIRT-1)/FoxO3a in the expression of cysteine-rich protein 61 (CYR-61) in rheumatoid arthritis synovial fibroblasts ( RASFs ) and the influence of simvastatin on this pathway, and to determine the relationship between disease progression and FoxO3a/CYR-61 signaling in synovial fibroblasts in vivo using a rat model of collagen induced arthritis ( CIA )