Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Pankratz et al., J Biol Chem 2009 (Breast Neoplasms...) : Collectively, our data indicate that Irs-2, but not Irs-1, promotes invasion by sustaining the aerobic glycolysis of mouse mammary tumor cells and that it does so by regulating the mTor dependent surface expression of Glut1
Wieman et al., Mol Biol Cell 2007 : Although Akt did not require mTOR/RAPTOR to maintain surface Glut1 levels, inhibition of mTOR/RAPTOR by rapamycin greatly diminished glucose uptake, suggesting Akt stimulated mTOR/RAPTOR may promote Glut1 transporter activity
Buller et al., American journal of physiology. Renal physiology 2011 (Diabetic Nephropathies...) : GLUT1 enhances mTOR activity independently of TSC2 and AMPK ... We sought to examine whether enhanced GLUT1 expression increased mTOR activity and, if so, to identify the mechanism ... In cells lacking functional tuberous sclerosis complex (TSC) 2, GLUT1 effects on mTOR activity persisted, indicating that GLUT1 effects were not mediated by TSC ... Conversely, enhanced GLUT1 expression led to a 2.4-fold increase in binding of mTOR to its activator, Rheb, and a commensurate 2.1-fold decrease in binding of Rheb to glyceraldehyde 3-phosphate dehydrogenase ( GAPDH ) consistent with mediation of GLUT1 effects by a metabolic effect on GAPDH
Buller et al., Am J Physiol Cell Physiol 2008 : These increases in glucose uptake and GLUT1 levels were prevented by inhibition of mTOR with rapamycin