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SLC22A3 — SMAD1
Text-mined interactions from Literome
Rhyu et al., J Am Soc Nephrol 2005
(Fibrosis...) :
Phosphorylation of
Smad proteins and/or mitogen activated protein kinases ( MAPK ) is
required for TGF-beta1 induced
EMT
Desgrosellier et al., Dev Biol 2005
:
Smad6, an inhibitor of
Smad signaling downstream of ALK2, but not ALK5,
inhibited EMT in AV cushion endocardial cells
Liu et al., Perit Dial Int 2008
(Fibrosis...) :
Phosphorylation of
Smad proteins is
required for TGFbeta1 induced
EMT
Miyazono et al., Proc Jpn Acad Ser B Phys Biol Sci 2009
(Disease Progression...) :
Multiple transcription factors, including deltaEF1/ZEB1, SIP1/ZEB2, and Snail/SNAI1, are induced by
TGF-beta-Smad signaling and
play critical roles in TGF-beta induced
EMT ... In addition, both
non-Smad signaling activated by TGF-beta and cross-talk with other signaling pathways
play important roles in induction of
EMT
Zhou et al., J Am Soc Nephrol 2010
:
Because Smad proteins transduce TGF-beta signaling from the cytosol to the nucleus and HSP72 assists in protein folding and facilitates nuclear translocation, we investigated whether HSP72
inhibits TGF-beta induced
EMT by modulating
Smad expression, activation, and nuclear translocation
Townsend et al., Cells Tissues Organs 2011
:
Targeting of Smad4, the common mediator Smad, demonstrated that
Smad signaling is
required for
EMT in the AVC and TGFßR3 dependent EMT stimulated by TGFß2 or BMP-2 ... Although we show that Smads 1, 2, 3, and 5 are required for AVC EMT, overexpression of
Smad1 or Smad3 is not
sufficient to induce
EMT
Park et al., Cancer Sci 2011
(Cell Transformation, Neoplastic...) :
The novel ALK5 inhibitor, EW-7203, efficiently
inhibited TGF-ß1 induced
Smad signalling,
EMT and breast tumor metastasis to the lung in vivo, demonstrating that EW-7203 has therapeutic potential for breast cancer metastasis to the lung
Ai et al., J Natl Cancer Inst 2011
(Adenocarcinoma...) :
Furthermore, high expression of pIgR was sufficient to
induce EMT through activation of
Smad signaling