Gene interactions and pathways from curated databases and text-mining

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OPN1LW — SMAD4

Text-mined interactions from Literome

Haller et al., J Biol Chem 2003 (Bacteroides Infections) : In addition, TGF-beta1 and Ad5Smad3/4 prevent B. vulgatus/LPS induced CBP/p300 and p65 nuclear co-association
Janknecht et al., Genes Dev 1998 : We report that TGF-beta receptor phosphorylation of Smad3 promotes its interaction with the paralogous coactivators CBP and p300, whereas CBP/p300 binding to nonphosphorylated Smad3 or its oligomerization partner Smad4 is negatively regulated by Smad-intramolecular interactions ... Thus, CBP/p300 are important components of activin/TGF-beta signaling and may mediate the antioncogenic functions of Smad2 and Smad4