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SMAD6 — TGFB1

Text-mined interactions from Literome

Piek et al., Int J Cancer 1999 (Glioblastoma...) : TGF-beta1 induced endogenous PAI-1 protein synthesis, Smad binding element/ ( CAGA ) 12-luciferase-reporter activity, as well as mRNA expression of Smad6 and Smad7 in all gliomas
Pouliot et al., Int J Cancer 1999 (Breast Neoplasms...) : Moreover, we show that the proliferative and transcriptional responses to TGF-beta1 are dissociable and that Smad expression is not regulated by sex steroids in ZR-75-1 cells
Poncelet et al., Kidney Int 1999 : Because several models of glomerulosclerosis suggest a role for TGF-beta in the extracellular matrix accumulation, we sought to characterize the role of SMAD proteins in mediating TGF-beta1 responses in a more physiological system using nontransformed human mesangial cells
Fanayan et al., J Biol Chem 2000 (Breast Neoplasms) : Phosphorylation of each Smad was stimulated by TGF-beta1 and, independently, by IGFBP-3 with the two agents together showing a cumulative effect
Buenemann et al., Carcinogenesis 2001 : Transforming growth factor-beta1 induced Smad signaling, cell-cycle arrest and apoptosis in hepatoma cells
Yakymovych et al., FASEB J 2001 : Here we provide a mechanism through which Smad dependent TGF-b signaling is modulated by protein kinase C ( PKC )
Blanchette et al., J Biol Chem 2001 : Conversely, overexpression of a constitutively active form of MEK1 increased unstimulated, TGF beta 1-stimulated , and Smad2 stimulated promoter P1 transactivation, and the universal Smad inhibitor, Smad7, inhibited this effect
Chipuk et al., J Biol Chem 2002 (Adenocarcinoma...) : In the prostate, androgens negatively regulate the expression of transforming growth factor-beta ( TGF-beta ) ligands and receptors and Smad activation through unknown mechanisms
Fanayan et al., J Biol Chem 2002 (Breast Neoplasms) : We previously demonstrated in T47D cells transfected to express the transforming growth factor-beta receptor type II ( TGF-betaRII ) that insulin-like growth factor binding protein-3 ( IGFBP-3 ) could stimulate Smad2 and Smad3 phosphorylation, potentiate TGF-beta1 stimulated Smad phosphorylation, and cooperate with exogenous TGF-beta1 in cell growth inhibition ( Fanayan, S., Firth, S. M., Butt, A. J., and Baxter, R. C. ( 2000 ) J. Biol. Chem. 275, 39146-39151 )
Prokova et al., J Biol Chem 2002 (Cell Transformation, Neoplastic) : Inhibition of transforming growth factor beta signaling and Smad dependent activation of transcription by the Latent Membrane Protein 1 of Epstein-Barr virus
Arsura et al., Oncogene 2003 (Carcinoma, Hepatocellular...) : Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis : implications in liver tumor formation
Kitamura et al., Pathol Int 2003 (Hepatitis C, Chronic...) : Immunocytochemical assay demonstrated that the TGF-beta1 stimulation induced the increase of the Smad expressions and the decrease of the autocrine TGF-beta1 in the HSC line ... These observations suggest that the Smad expressions increase in the nucleus of the HSC in the cirrhotic liver and that the TGF-beta1 stimulation induces the Smad expression
Xu et al., J Clin Endocrinol Metab 2003 (Leiomyoma) : TGFbeta1 increased the rate of Smad and phosphorylated Smad3 ( pSmad3 ) induction in both cell types
Chai et al., J Biol Chem 2003 : The Smad family of proteins mediates transforming growth factor-beta signaling from cell membrane to the nucleus
Mori et al., Int J Cancer 2003 (Carcinoma, Hepatocellular...) : Repression of Smad dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB
Peltier et al., Kidney Int 2003 (Inflammation) : Transforming growth factor-beta 1 increases glucocorticoid binding and signaling in macrophages through a Smad- and activated protein-1 mediated process
Yang et al., Am J Pathol 2003 (Fibrosis) : To decipher the mechanism underlying HGF antagonizing TGF-beta1 's action, we examined the effects of HGF on TGF-beta1 mediated Smad signaling
Yang et al., J Am Soc Nephrol 2003 (Fibrosis...) : Both SnoN and Ski could block Smad mediated activation of TGF-beta1-responsive promoter and exhibited additive effect in abrogating the profibrotic actions of TGF-beta1
Qiu et al., J Mol Cell Cardiol 2003 : In this study, we used the TGF-beta1 treated 10T1/2 cells as an in vitro model to understand how Smad mediated TGF-beta1 signals regulate SM22 promoter transcription during myofibroblast differentiation
Dai et al., J Am Soc Nephrol 2004 : Ectopic expression of TGIF markedly suppressed Smad mediated activation of TGF-beta1-responsive promoter activity and completely blocked TGF-beta1 induced alpha-smooth muscle actin expression
Han et al., J Biol Chem 2004 (Liver Neoplasms) : Furthermore, the TGF-beta1 induced Smad transcriptional activity and mitoinhibition were blocked by overexpression of cPLA2alpha or peroxisome proliferator activated receptor-gamma ( PPAR-gamma ) but enhanced by depletion of cPLA2alpha or PPAR-gamma
Ungefroren et al., J Biol Chem 2005 : We have recently shown that induction of biglycan (BGN) expression by transforming growth factor-beta1 ( TGF-beta1 ) required sequential activation of both Smad and p38 mitogen activated protein kinase signaling ( Ungefroren, H., Lenschow, W., Chen, W.-B., and Kalthoff, H. ( 2003 ) J. Biol. Chem. 278, 11041-11049 )
Wang et al., J Biol Chem 2005 : Recently, we found that enforced expression of ARA55 inhibits transforming growth factor-beta mediated up-regulation of Smad binding element-luciferase reporter activity in NRP-154 and NRP-152 rat prostate and LNCaP human prostate cell lines
Zhang et al., J Biol Chem 2005 : Increased TGF-beta1 dependent Smad signaling by IL-6 was significantly attenuated by inhibition of clathrin mediated endocytosis and augmented by depletion of membrane cholesterol
Ruiz et al., J Immunol 2005 (Colitis...) : Of note, TGF-beta1 activated Smad signaling was associated with the loss of TLR2 protein expression and the inhibition of NF-kappaB dependent gene expression in IEC lines
Kim et al., Invest Ophthalmol Vis Sci 2005 : To evaluate the effects of TGF-beta1 and doxycycline on production of gelatinase MMP-9 and activation of Smad , c-Jun N-terminal kinase (JNK), extracellular regulated kinase (ERK), and p38 mitogen activated protein kinase ( MAPK ) signaling pathways in human corneal epithelial cells
Birukova et al., FEBS Lett 2005 : Thus, our data demonstrate for the first time direct link between TGF-beta1 mediated activation of ALK5/Smad and EC barrier dysfunction
Guo et al., Kidney Int 2005 (MAP Kinase Signaling System) : TGF-beta1 also stimulated nuclear translocation of Smads and binding to palindromic Smad binding element ( SBE ) located in the rat PAI-1 promoter, without being affected by MEK inhibitor
Li et al., J Am Soc Nephrol 2006 (Fibrosis) : Both HGF and 15d-PGJ2 attenuated Smad nuclear translocation in response to TGF-beta1 stimulation in renal fibroblasts
Pring et al., Int J Oncol 2006 (Head and Neck Neoplasms) : Dysregulated TGF-beta1 induced Smad signalling occurs as a result of defects in multiple components of the TGF-beta signalling pathway in human head and neck carcinoma cell lines ... The results demonstrate that deregulated TGF-beta1 induced Smad signalling is common in HNSCC cell lines and can occur as a result of a variety of defects in the TGF-beta signal transduction pathway
Liu et al., Med Hypotheses 2006 : Therefore, the activation of Smad signalling induced by TGF-beta(1) plays a key role in the mechanism of renal tubular EMT, and in this process, Arkadia may has an important influence on the mechanism above mentioned through degradation of Smad7
Inamoto et al., Oncogene 2007 : Crk associated substrate lymphocyte type regulates transforming growth factor-beta signaling by inhibiting Smad6 and Smad7
Cho et al., Cytokine 2006 (Liver Cirrhosis) : Oltipraz inhibited the ability of TGFbeta1 to induce PAI-1, as indicated by repression of TGFbeta1 mediated luciferase induction from the plasmid comprising the human PAI-1 promoter and of TGFbeta1 induced Smad-DNA binding activity
Wu et al., Cancer Metastasis Rev 2006 (Disease Progression...) : AP-1 and Smad can be activated by PKC activator and TGF-beta1 , respectively, in a ROS dependent manner
Kim et al., Arch Pharm Res 2007 : Although it has been demonstrated that p21WAF1/Cip1 could be induced by transforming growth factor-beta1 ( TGF-beta1 ) in a Smad dependent manner, the cross-talk of Smad signaling pathway with other signaling pathways still remains poorly understood
Li et al., Circ Res 2008 : Atrial natriuretic peptide inhibits transforming growth factor beta induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts
Horie et al., J Lipid Res 2008 : One of the genes identified was TG-interacting factor (TGIF), a DNA binding homeodomain protein that has been demonstrated to suppress Smad mediated activation of transforming growth factor beta ( TGF-beta ) -regulated transcription
Kunzmann et al., Int Arch Allergy Immunol 2008 : Furthermore, rCTGF did not attenuate TGF-beta(1) mediated inhibition of CD4+ T lymphocyte proliferation and TGF-beta(1) induced Smad signaling in CD4+ T lymphocytes
Diamond et al., J Cell Sci 2008 (Carcinoma, Squamous Cell...) : Mechanistically, EGF enhanced Smad phosphorylation in the linker region, and attenuated TGFbeta1 mediated phosphorylation of Smad at the C-terminus, localization of Smad to the nucleus as well as Smad-driven promoter activity exclusively in oral keratinocytes but not in OSCC cells
Ng et al., Am J Nephrol 2009 (Disease Models, Animal...) : Further studies revealed that severe renal fibrosis was associated with upregulation of renal TGF-beta1 and activation of TGF-beta/Smad signaling, which was blocked by treatment with PTX
Truty et al., J Biol Chem 2009 : The role of non-Smad proteins in the regulation of transforming growth factor-beta ( TGFbeta ) signaling is an emerging line of active investigation
Hills et al., American journal of physiology. Renal physiology 2009 (Diabetic Nephropathies) : C-peptide also blocked TGF-beta1 induced upregulation of expression of both type I and type II TGF-beta1 receptors and attenuated TGF-beta1 mediated Smad phosphorylation and Smad transcriptional activity
Webber et al., J Biol Chem 2009 : Similarly inhibition of HAS2 by short interfering RNA prevented phenotypic activation without altering TGF-beta1 dependent Smad phosphorylation, thus suggesting that HA-dependent regulation of cell phenotype was independent of Smad activation
Gong et al., Biol Reprod 2009 : Furthermore, SMAD3 interacts with a palindromic SMAD binding element in the Fshr promoter, and TGFB can activate promoter constructs containing this element
Lee et al., Mol Biol Cell 2009 (Teratocarcinoma) : Here, we report that although the transforming growth factor ( TGF ) -beta type III receptor ( TbetaRIII ) enhanced both ALK3 and ALK6 signaling, TbetaRIII more potently enhanced ALK6 mediated stimulation of the BMP-responsive promoters XVent2 and 3GC2, and up-regulation of the early response gene Smad6
Massuto et al., Reproduction 2010 : TGFB signals via TGFBR and activates downstream effector SMAD proteins 2 and 3 ( p-SMAD2/3 )
Chen et al., Exp Cell Res 2010 : We examined the effect of EPO on TGF-beta1 mediated Smad signaling
Huang et al., Journal of neuroinflammation 2010 : TGF-beta1 blockade of microglial chemotaxis toward Abeta aggregates involves SMAD signaling and down-regulation of CCL5
Kim et al., Cell Prolif 2010 (MAP Kinase Signaling System) : On the other hand, TGF-beta1 signalling also led to SMAD activation that could directly increase chondrogenic activity of ASCs
Tang et al., PloS one 2012 (Liver Cirrhosis) : The hepatoprotective effects of AA on fibrosis were associated with upregulation of hepatic Smad7, an inhibitor of TGF-beta signaling, thereby blocking upregulation of TGF-beta1 and CTGF and the activation of TGF-beta/Smad signaling
Eloy et al., Virchows Arch 2012 (Carcinoma...) : It was also shown that transforming growth factor beta ( TGF-beta ) /Smad dependent pathway activity is associated with local invasion, nodal metastatization and BRAF mutated PTCs
Afrakhte et al., Biochem Biophys Res Commun 1998 (Lung Neoplasms) : Smad6 and Smad7 mRNAs were differentially expressed in lung cancer cell lines and were rapidly and directly induced by TGF-beta1 , activin and bone morphogenetic protein-7