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ESR1 — SNCG

Text-mined interactions from Literome

Jiang et al., Cancer Res 2003 (Breast Neoplasms) : A notable finding in this study is that SNCG , identified previously as a breast cancer-specific gene 1, strongly stimulated the ligand dependent transcriptional activity of estrogen receptor-alpha (ER-alpha) in breast cancer cells ... Augmentation of SNCG expression stimulated transcriptional activity of ER-alpha, whereas compromising endogenous SNCG expression suppressed ER-alpha signaling ... The SNCG stimulated ER-alpha signaling was demonstrated in three different cell systems including ER-alpha positive and SNCG negative MCF-7 cells, ER-alpha positive and SNCG positive T47D cells, and SNCG negative and ER-alpha negative MDA-MB-435 cells ... These data indicate that SNCG is required for efficient ER-alpha signaling and, thus, stimulated hormone-responsive mammary tumors
Jiang et al., Cancer Res 2004 (Breast Neoplasms) : Gamma synuclein , a novel heat-shock protein associated chaperone, stimulates ligand dependent estrogen receptor alpha signaling and mammary tumorigenesis ... As an ER-alpha associated chaperone, SNCG participated in Hsp-ER-alpha complex, enhanced the high-affinity ligand binding capacity of ER-alpha, and stimulated ligand dependent activation of ER-alpha
Shi et al., Am J Pathol 2010 : However, expression of SNCG prevented ER-alpha36 degradation and completely recovered 17-AAG mediated down-regulation of estrogen signaling