Gene interactions and pathways from curated databases and text-mining

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INS — SOS1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

He et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Insulin dependent translocation of Shc, SOS1 , and MAPK to lipid raft microdomains was markedly attenuated by FLNa expression
Waters et al., Mol Cell Biol 1995 : Further, incubation of whole-cell extracts with glutathione-S-transferase-Grb2 fusion proteins demonstrated that insulin stimulation resulted in a decreased affinity of SOS for Grb2
Holt et al., Mol Cell Biol 1996 : Expression of a dominant interfering MEK mutant, in which lysine 97 was replaced with arginine ( MEK/K97R ), resulted in an inhibition of insulin stimulated SOS and ERK phosphorylation, whereas expression of a constitutively active MEK mutant, in which serines 218 and 222 were replaced with glutamic acid ( MEK/EE ), induced basal phosphorylation of both SOS and ERK
Dong Chen et al., J Biol Chem 1996 : Insulin and osmotic shock, but not anisomycin, resulted in SOS phosphorylation and disassociation of the Grb2-SOS complex, demonstrating that the JNK pathway was not involved in the insulin stimulated feedback uncoupling of the Grb2- SOS complex
Corbalan-Garcia et al., Oncogene 1996 : In rat L6 cells, insulin induced Sos phosphorylation is accompanied by a partial dissociation of the Grb2-Sos complex ... We show that in rat L6 cells, cAMP treatment prevents both the insulin stimulated Sos phosphorylation and Grb2 dissociation
Schubert et al., J Biol Chem 1996 (Second Messenger Systems) : Thus, it appears that in 3T3-L1 adipocytes, PKC has a constitutive inhibitory effect on GAP that permits insulin to activate Sos and p21(ras)
Srinivas et al., Cell Signal 1996 : alpha 2-HSG inhibits insulin induced tyrosine phosphorylation of IRS-1 and the subsequent association of GRB2, as well as Sos , with IRS-1
Ishiki et al., Endocrinology 1997 : Neither insulin nor EGF treatment induced Crk-II association with either Sos or C3G