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NGF — SOS2

Text-mined interactions from Literome

Basu et al., Oncogene 1994 : The binding of Sos to tyrosine phosphorylated receptor, via Grb2 may also contribute to Ras activation by EGF but not NGF , while stable complex formation between Shc and receptors is not necessary for Ras activation by either growth factor
Kouhara et al., Cell 1997 : In this report, we describe the purification, cloning, and characterization of a novel protein, designated FRS2, that is tyrosine phosphorylated and binds to Grb2/Sos in response to FGF or NGF stimulation
Meakin et al., J Neurochem 1998 : Although the stoichiometry of TrkAS3-SHC binding is reduced, cells overexpressing TrkAS3 exhibit NGF dependent SHC-Grb-2/Sos binding, essential for Ras activation, as well as NGF dependent SNT phosphorylation to absolute levels comparable to those in PC12 cells