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INS — ST3GAL4

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Kim et al., Am J Physiol 1999 (Body Weight...) : Effects of streptozotocin (STZ) induced diabetes and insulin on opioid peptide gene expression were examined in rats
Dehghani et al., Indian J Med Res 1999 (Diabetes Mellitus, Experimental...) : Trophic effects of vanadium on beta-cells of STZ induced insulin dependent diabetic rats & evidence for long-term relief of diabetes mellitus
Elangovan et al., Free radical research 2000 (Body Weight...) : In the present study, the overall LMWA capacity ( reducing equivalents ) of plasma and tissues of streptozotocin (STZ) induced diabetic rats ( 1-4 weeks ) and insulin treated diabetic rats were measured by cyclic voltammetry
Andersson et al., J Pineal Res 2001 (Diabetes Mellitus, Experimental...) : We found that melatonin counteracted STZ induced inhibition of glucose metabolism and insulin release in cultured rat islets after 18 hr of recovery
Friesen et al., Diabetologia 2004 (Diabetes Mellitus, Experimental) : Both STZ and H2O2 dose-dependently inhibited the release of immunoreactive insulin after a D-glucose challenge
Yamamoto et al., J Physiol Sci 2009 (Diabetes Mellitus, Experimental...) : These findings suggested that the STZ induced chronic insulin-deficiency was an important causal factor for the attenuation of VRAC current
Nizamutdinova et al., Mol Nutr Food Res 2009 (Body Weight...) : ANT not only enhanced STZ mediated insulin level decreases, but also decreased the triglyceride levels induced by STZ injection in serum
Kwon et al., J Pharmacol Sci 2009 (Body Weight...) : At hyperglycemic clamp, STZ attenuated both first and second phase insulin secretion in STZ- and saline treated Px rats, but exendin-4 incompletely reversed the attenuation
Ning et al., Am J Physiol Endocrinol Metab 2011 (Carcinoma, Hepatocellular...) : The HFD induced insulin resistance was prevented largely by the streptozotocin (STZ) induced moderate insulin deficiency ... The STZ induced insulin deficiency prevented the HFD induced ectopic fat accumulation and oxidative stress in liver and gastrocnemius ... The STZ induced insulin deficiency prevented the HFD- or insulin induced increase in hepatic expression of long-chain acyl-CoA synthetases ( ACSL ), which are necessary for fatty acid activation ... HFD increased mitochondrial contents of long-chain acyl-CoAs, whereas it decreased mitochondrial ADP/ATP ratio, and these HFD induced changes were prevented by the STZ induced insulin deficiency
Devi et al., PloS one 2012 (Alzheimer Disease...) : Importantly, STZ induced insulin deficiency upregulated levels of both ß-site APP cleaving enzyme 1 ( BACE1 ) and full-length APP in 5XFAD mouse brains, which was accompanied by dramatic elevations in the ß-cleaved C-terminal fragment ( C99 )
Eizirik et al., Braz J Med Biol Res 1985 (Diabetes Mellitus, Experimental) : The streptozotocin (STZ) induced inhibition of insulin release by isolated islets was measured in islets of rats previously adapted to either a high-protein ( HP ) or a balanced control diet
Philipps et al., Diabetes 1986 (Diabetes Mellitus, Experimental...) : To investigate this question, streptozocin (STZ) was injected into 10 late-gestation fetal lambs, and the effects of STZ on fetal pancreatic insulin storage and secretion, fetal metabolic rate, and umbilical glucose uptake were then studied
Welle et al., J Neural Transm 1987 : STZ induced insulin deficiency caused hyperglycemia and hyperphagia, but also did not alter cardiac NE content or turnover
Ziegler et al., Exp Clin Endocrinol 1985 : STZ caused a dose dependent decrease of pancreatic insulin whereas the glucagon content was significantly enhanced in diabetic animals
Nakadate et al., Eur J Pharmacol 1981 (Diabetes Mellitus, Experimental) : Acute changes in phase glucose and insulin levels induced by STZ were potentiated by yohimbine but not by prazosin
Huang et al., Pediatr Res 1984 (Diabetes Mellitus, Experimental...) : Protective effect of pertussis vaccine ( PV ) against the development of insulin dependent diabetes (IDD) induced by streptozotocin (STZ) in young CD-1 male mice were studied
Bouix et al., Horm Metab Res 1995 (Diabetes Mellitus, Experimental) : In vitro experiment on isolated pancreatic islets demonstrated that STZ induced loss of insulin response to glucose was also counteracted by incubation with GHB and NA ( Peak insulin response to 16.4 mM glucose : 0.69 +/- 0.31 vs 3.03 +/- 0.67 microU/islet/min ), but not by GHB or NA alone
Ogawa et al., Eur J Endocrinol 1995 : These results indicate that STZ affects the production of follistatin or beta-subunits of inhibin/activin in pancreatic B cells rather than insulin secretion
Delaney et al., Biochem Pharmacol 1995 : Lack of involvement of nitric oxide was further suggested by the failure of oxyhaemoglobin to reverse STZ and MNU inhibition of insulin secretion
Dall'Ago et al., Braz J Med Biol Res 1997 (Bradycardia...) : STZ induced hyperglycemia ( 447 +/- 49 vs 126 +/- 3 mg/dl ), and a reduction in AP ( 99 +/- 3 vs 118 +/- 2 mmHg ), resting HR ( 296 +/- 11 vs 355 +/- 16 bpm ) and plasma insulin levels ( 16 +/- 1 vs 57 +/- 11 microU/ml )