Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kim et al., J Biol Chem 2009 (Diabetes Mellitus, Type 2...) : Our results also indicated that mammalian target of rapamycin was likely responsible for the phosphorylation of STAT3 at Ser ( 727 ) in response to excess amino acids
Magri et al., Cell stem cell 2011 (Epilepsy...) : Notably, mTORC1 dependent Akt inhibition and STAT3 activation were involved in the reduced self-renewal and earlier neuronal and astroglial differentiation of mutant NSCs
Kusaba et al., J Biol Chem 2005 : In accordance with this, reduction in the mTOR protein level by small interfering RNA resulted in suppression of Stat3 phosphorylation and decreased production of IFN-gamma after IL-12 stimulation
Yokogami et al., Curr Biol 2000 (MAP Kinase Signaling System) : Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
Riemenschneider et al., Cancer Res 2006 (Glioblastoma) : mTOR activation results in subsequent activation of S6K and STAT3 , as well as suppression ( i.e., phosphorylation ) of 4E-BP1, leading to cell cycle progression and inhibition of apoptosis
Yang et al., J Biol Chem 2013 (Neoplasms...) : The interaction of Gadd45a with mTOR suppresses STAT3 phosphorylation at Ser-727 and leads to down-regulated expression of VEGFa
Kim et al., J Biol Chem 2008 (Carcinoma, Hepatocellular...) : Interestingly, we find that the phosphorylation of STAT3 on Ser ( 727 ) and STAT3 transcriptional activity are regulated by mTOR upon IL-6 stimulation and that STAT3 is required for IL-6 inhibition of insulin signaling