◀ Back to SAA1

SAA1 — STAT3

Text-mined interactions from Literome

Hagihara et al., Genes Cells 2005 : Essential role of STAT3 in cytokine-driven NF-kappaB mediated serum amyloid A gene expression ... Here we provide evidence that STAT3 plays an essential role in cytokine-driven SAA expression, although the human SAA gene shows no typical STAT3 response element ( RE ) in its promoters ... Moreover, co-expression of p300 with STAT3 dramatically enhances the transcriptional activity of SAA ... The formation of a complex with STAT3 , NF-kappaB p65, and p300 is thus essential for the synergistic induction of the SAA gene by IL-1+6 stimulation
Shinriki et al., J Oral Pathol Med 2010 (Carcinoma, Squamous Cell...) : An inhibitor of STAT3 activation, AG490, significantly reduced SAA1 expression in SAS cells
Plum et al., Am J Pathol 2010 (Cholangitis, Sclerosing...) : These mice also displayed increased tumor necrosis factor-alpha expression, a diminished acute-phase response ( lack of STAT3 and serum amyloid A activation ), and enhanced immune cell infiltration in the liver
Migita et al., J Rheumatol 2011 (Acute-Phase Reaction...) : Our data indicated that CP690,550 blocked IL-6 induced JAK2/STAT3 activation, as well as the induction of A-SAA