Nakashima et al., J Bone Joint Surg Am 1999
(Prosthesis Failure) :
These data suggest that particle induced macrophage release of TNF-alpha and IL-6 does not require phagocytosis but is dependent on tyrosine and serine/threonine kinase activity culminating in activation of
Goldstein et al., J Immunol 1993
:
Our study demonstrated that IL-2, IL-4, and IL-6-stimulation of IgM secretion by SKW6.4 cells was inhibited by either the serine/threonine kinase inhibitor, 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperizine dihydrochloride ( H7 ) or the tyrosine kinase inhibitor, genistein ... Taken together, our data demonstrate that activation of both a serine/threonine kinase and a tyrosine kinase is involved in the IL-2, IL-4, and IL-6-stimulation of IgM secretion by SKW6.4 cells and activation of the same or a similar serine/threonine protein kinase is an early step in the signal transduction pathway used by these cytokines