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Wong et al., Pathology 2001 (Breast Neoplasms) : The aim of this study was to assess the effects of transforming growth factor-beta1 ( TGFbeta1 ), insulin-like growth factor-I (IGF-I) and insulin-like growth factor-II (IGF-II) on cell growth, E1STS and E2DH activities in the MCF-7 and MDA-MB-231 human breast cancer cell lines
Nestler et al., Horm Metab Res 1989 : A possible mechanism for this phenomenon would be an insulin mediated increase in steroid sulfatase activity, with insulin acting either via activation of the insulin receptor or via cross-reaction with the insulin-like growth factor I (IGF-I) receptor ... These data indicate that neither insulin nor IGF-I affect the steroid sulfatase activity of human cytotrophoblasts ... An effect of insulin or IGF-I on the steroid-sulfatase activity of other tissues has not been excluded ... These observations suggest that the decline in serum DHEA-S levels during hyperinsulinemia is not mediated via an insulin induced increase in steroid sulfatase activity