Gene interactions and pathways from curated databases and text-mining

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AKT3 — TAS2R13

Text-mined interactions from Literome

He et al., J Biol Chem 2006 (Diabetes Mellitus, Experimental...) : Role of TRB3 in inhibition of Akt/protein kinase B activation
Koh et al., Mol Cell Biol 2006 (Insulin Resistance) : Akt/TRB3 binding was present in skeletal muscle, and overexpression of TRB3 in C2C12 myoblasts significantly reduced Akt phosphorylation
Kato et al., Biochem Biophys Res Commun 2007 : Our data indicated that the expression of TRB3 is downregulated during C2C12 cells undergoing muscle differentiation and that overexpression of TRB3 inhibits Akt activation during differentiation
Ding et al., Exp Cell Res 2008 : TRB3 negatively regulates Akt activation and noticeably, TRB3 expression is induced by insulin
Bi et al., Endocr J 2008 (Metabolic Syndrome X) : The present study suggests that TRB3 may be involved in metabolic syndrome by inhibiting activation of Akt in adipose tissue
Cravero et al., Arthritis Rheum 2009 (Osteoarthritis, Knee) : TRB3 , a tribbles homolog, has been shown to inhibit IGF-1 mediated activation of Akt in HEK 293 cells ... Overexpression of TRB3 inhibited Akt phosphorylation and reduced chondrocyte survival and proteoglycan synthesis
Morse et al., Mol Immunol 2009 : TRB3 has been shown to inhibit the phosphorylation of AKT/Protein Kinase B, and reduced activation of AKT has been associated with decreased cellular divisions and survival ... However in lymphocytes, TRB3 did not reduce the phosphorylation of AKT , and WY14,643 treatment was associated with enhanced activation of AKT