Saito et al., Cancer Cell 2007
(Lymphoma, B-Cell...) :
Activation of the CD40 receptor leads to NF-kappaB mediated induction of the IRF4 transcription factor , which, in turn, represses BCL6 expression by binding to its promoter region
Karras et al., J Immunol 1997
:
We show here that CD40 engagement on murine B cells results in the rapid tyrosine phosphorylation of the STAT6 transcription factor and the transactivation of a reporter gene containing an IFN-regulatory factor-1 STAT binding site