Gene interactions and pathways from curated databases and text-mining

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BTRC — TCF3

Text-mined interactions from Literome

Meimoun et al., Mol Biol Cell 2000 : Here we report that SCF ( CDC4 ), a recently characterized protein complex that acts in conjunction with the ubiquitin conjugating enzyme Cdc34 to degrade cell cycle regulators, is also necessary for the degradation of the transcription factor Gcn4. Degradation of Gcn4 occurs throughout the cell cycle, whereas degradation of the known cell cycle substrates of Cdc34/SCF(CDC4) is cell cycle regulated
Nakajima et al., Arch Dermatol Res 2012 (Hyperpigmentation) : Real-time RT-PCR and western blotting of Ax-treated HEEs revealed that the SCF stimulated expression of tyrosinase (TYR), TYR related protein-1 (TYRP1), and Pmel17, as well as microphthalmia associated transcription factor ( MITF ), is significantly suppressed by Ax at the transcriptional and translational levels