Gene interactions and pathways from curated databases and text-mining

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HSPG2 — TERF2

Text-mined interactions from Literome

Guidetti et al., Journal of thrombosis and haemostasis : JTH 2009 : Platelet adhesion promoted by integrin alpha2beta1 induces integrin alpha ( IIb ) beta3 activation through the phospholipase C (PLC) dependent stimulation of the small GTPase Rap1b
Dzhura et al., Islets 2011 : Since the KO of PLC-e disrupts the ability of 8-pCPT-2'-O-Me-cAMP-AM to potentiate GSIS, while also disrupting its ability to stimulate an increase of ß-cell [ Ca2+ ] i, the available evidence indicates that it is a Rap1 regulated PLC-e that links Epac2 activation to Ca2+ dependent exocytosis of insulin
M'Rabet et al., Blood 1998 : Finally, we found that Rap1 is activated by both the Ca2+ ionophore ionomycin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate ( TPA ), indicating that phospholipase C (PLC) activation leading to elevated levels of intracellular free Ca2+ and diacylglycerol ( DAG ) can mediate Rap1 activation