Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Roczniak-Ferguson et al., Science signaling 2012 : When lysosomal activity was adequate, mTOR dependent phosphorylation of TFEB on Ser ( 211 ) triggered the binding of 14-3-3 proteins to TFEB, resulting in retention of the transcription factor in the cytoplasm ... Inhibition of lysosomal function reduced the mTOR dependent phosphorylation of TFEB , resulting in diminished interactions between TFEB and 14-3-3 proteins and the translocation of TFEB into the nucleus, where it could stimulate genes involved in lysosomal biogenesis
Zhou et al., Cell Res 2013 : Third, we examined the involvement of transcription factor EB (TFEB) and demonstrated that TFEB activation following mTORC1 suppression is necessary but not sufficient for lysosomal activation
Peña-Llopis et al., EMBO J 2011 (MAP Kinase Signaling System) : Regulation of TFEB and V-ATPases by mTORC1 ... mTORC1 coordinately regulates TFEB phosphorylation and nuclear localization and in a manner dependent on both TFEB and V-ATPases, mTORC1 promotes endocytosis
Martina et al., J Cell Biol 2013 : Interaction of TFEB with active Rag heterodimers promoted recruitment of TFEB to lysosomes, leading to mTORC1 dependent phosphorylation and inhibition of TFEB
Settembre et al., EMBO J 2012 : Conversely, pharmacological inhibition of mTORC1 , as well as starvation and lysosomal disruption, activates TFEB by promoting its nuclear translocation