Gene interactions and pathways from curated databases and text-mining

◀ Back to EPHB2

EPHB2 — TH

Text-mined interactions from Literome

Haycock et al., Proc Natl Acad Sci U S A 1992 : ERK1 and ERK2, two microtubule associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ
Zhang et al., Neurosci Lett 2007 (Neoplasms) : Nurr1 is phosphorylated by ERK2 in vitro and its phosphorylation upregulates tyrosine hydroxylase expression in SH-SY5Y cells
Jacobsen et al., Neurobiol Dis 2008 (Neuroblastoma) : A Nurr1 point mutant, implicated in Parkinson 's disease, uncouples ERK1/2 dependent regulation of tyrosine hydroxylase transcription
Douglas et al., J Neuroendocrinol 2009 : This increase in the serine 31 phosphorylation of tyrosine hydroxylase was prevented by inhibition of protein kinase C or ERK1/2 activation
Obara et al., J Biol Chem 2009 : ERK5 activity is required for nerve growth factor induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells ... Both NGF and Bt ( 2 ) cAMP increased tyrosine hydroxylase gene promoter activity in an ERK1/2 dependent manner but was ERK5 independent ... Taking these results together, ERK5 is involved in neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells, and ERK5, along with ERK1/2, plays essential roles in the neural differentiation process
Knowles et al., J Neuroendocrinol 2011 : Protein kinase C activation by phorbol 12-myristate 13-acetate also caused an ERK1/2 dependent increase in the serine 31 phosphorylation of tyrosine hydroxylase but, in contrast to the nicotinic response, was not accompanied by an increase in enzyme activity ... Thus, ERK1/2 mediated serine 31 phosphorylation of tyrosine hydroxylase appears necessary but not sufficient for nicotinic activation of catecholamine synthesis in cervine chromaffin cells