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EPHB2 — TH
Text-mined interactions from Literome
Haycock et al., Proc Natl Acad Sci U S A 1992
:
ERK1 and ERK2, two microtubule associated protein 2 kinases,
mediate the phosphorylation of
tyrosine hydroxylase at serine-31 in situ
Zhang et al., Neurosci Lett 2007
(Neoplasms) :
Nurr1 is phosphorylated by
ERK2 in vitro and its phosphorylation
upregulates tyrosine hydroxylase expression in SH-SY5Y cells
Jacobsen et al., Neurobiol Dis 2008
(Neuroblastoma) :
A Nurr1 point mutant, implicated in Parkinson 's disease, uncouples
ERK1/2 dependent regulation of
tyrosine hydroxylase transcription
Douglas et al., J Neuroendocrinol 2009
:
This increase in the serine 31 phosphorylation of
tyrosine hydroxylase was
prevented by inhibition of protein kinase C or
ERK1/2 activation
Obara et al., J Biol Chem 2009
:
ERK5 activity is
required for nerve growth factor induced neurite outgrowth and stabilization of
tyrosine hydroxylase in PC12 cells ... Both NGF and Bt ( 2 ) cAMP increased
tyrosine hydroxylase gene promoter activity in an
ERK1/2 dependent manner but was ERK5 independent ... Taking these results together,
ERK5 is
involved in neurite outgrowth and stabilization of
tyrosine hydroxylase in PC12 cells, and ERK5, along with ERK1/2, plays essential roles in the neural differentiation process
Knowles et al., J Neuroendocrinol 2011
:
Protein kinase C activation by phorbol 12-myristate 13-acetate also caused an
ERK1/2 dependent increase in the serine 31 phosphorylation of
tyrosine hydroxylase but, in contrast to the nicotinic response, was not accompanied by an increase in enzyme activity ... Thus,
ERK1/2 mediated serine 31 phosphorylation of
tyrosine hydroxylase appears necessary but not sufficient for nicotinic activation of catecholamine synthesis in cervine chromaffin cells