Gene interactions and pathways from curated databases and text-mining

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EPHB2 — TIMP2

Text-mined interactions from Literome

Lee et al., Biochem Biophys Res Commun 2006 (Fibrosarcoma...) : Taken together, our data indicate that sPLA2 induced proMMP-2 activation is influenced by intracellular cAMP levels via the modulations of TIMP-2 expression and ERK1/2 activation
Biswas et al., Biochem Biophys Res Commun 2006 : SHP-2-Erk signaling regulates concanavalin A-dependent production of TIMP-2
D'Alessio et al., J Biol Chem 2008 : TIMP-2 binding to MT1-MMP induces activation of ERK1/2 by a mechanism that does not require the proteolytic activity and is mediated by the cytoplasmic tail of MT1-MMP
Sounni et al., Int J Cancer 2010 (Neoplasm Invasiveness) : Timp-2 binding with cellular MT1-MMP stimulates invasion promoting MEK/ERK signaling in cancer cells ... The TIMP-2 induced stimulation of ERK signaling in cancer cells explains the direct, as opposed to the inverse, association of TIMP-2 expression with poor prognosis in cancer
Gomes et al., BMC cancer 2012 (Breast Neoplasms...) : Moreover, ERK1/2 inhibition increased RECK and prevented the TGF-ß1 induction of pro-MMP-9 and TIMP-2 proteins