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TGFB1 — TIMP3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hoshino et al., Respiration 2001
:
Interleukin-1beta (IL-1beta) and
transforming growth factor-beta1 ( TGF-beta1 )
increased MMP-3 and
TIMP-3 expressions in A549 cells in a time- and concentration dependent manner ... IL-1beta mainly augmented MMP-3 expression, while
TGF-beta1 mainly
augmented TIMP-3 expression
Salmela et al., Mod Pathol 2003
(Graft vs Host Disease) :
In agreement with previous data on cancer cells,
TIMP-3 ,
induced by
TGF-beta1 , may contribute to the apoptosis of keratinocytes in cutaneous graft-versus-host disease lesions, leading to typical histopathological changes
Li et al., Free Radic Biol Med 2004
:
Transforming growth factor Beta1 induction of
tissue inhibitor of metalloproteinases 3 in articular chondrocytes is mediated by reactive oxygen species ...
TGF-beta1 induces
tissue inhibitor of metalloproteinases 3 ( TIMP-3 ), an inhibitor of cartilage damaging matrix metalloproteianases and aggrecanases ... We investigated the role of reactive oxygen species ( ROS ) in
TIMP-3 induction by
TGF-beta1 ... The
TIMP-3 increase
induced by
TGF-beta1 was partly Smad2 dependent ... Reduced glutathione and L-cysteine also blocked Smad2 and
TIMP-3 induction by
TGF-beta1 , whereas a nonthiol, N-acetylalanine, did not
Cross et al., Prostate 2005
(Prostatic Hyperplasia...) :
In stromal cells,
TGFbeta1 decreased ADAMTS-1, -5, -9, and -15 transcripts and
increased ADAMTS-4, versican, and
TIMP-3
García-Alvarez et al., Exp Lung Res 2006
(Pulmonary Fibrosis) :
The authors examined whether the MAPK pathway was involved in
TGF-beta1 induced
TIMP3 expression ... Our findings suggest that
TGF-beta1 induced
TIMP3 may be an important mediator in lung fibrogenesis
Qureshi et al., Cell Signal 2007
:
This study tested the hypothesis that Akt/protein kinase B signaling pathway could mediate
TGF-beta1 induction of
TIMP-3 in human articular chondrocytes
Tsuji et al., Spine (Phila Pa 1976) 2007
:
Decrease in expression of
TIMP-3 , possibly
mediated in part by
TGF-beta1 , may cause imbalance of ADAMTS4/TIMP-3 ratio at transition period from notochordal to fibrocartilaginous NP
El Mabrouk et al., J Cell Biochem 2008
:
IL-4 also downregulated
TGF-beta1 induced
TIMP-3 gene expression, Smad2, and JNK phosphorylation
Qureshi et al., Biochim Biophys Acta 2008
:
Smad signaling pathway is a pivotal component of
tissue inhibitor of metalloproteinases-3 regulation by
transforming growth factor beta in human chondrocytes ... Here we investigated previously unexplored roles of specific Smads in
TGF-beta1 induction of
TIMP-3 gene by pharmacological and genetic knockdown approaches ...
TGF-beta1 induced Smad2 phosphorylation and
TIMP-3 protein expression could be inhibited by the Smad2/3 phosphorylation inhibitors, PD169316 and SB203580 and by Smad2-specific siRNA
Morris et al., Connect Tissue Res 2010
:
Stimulation with Interleukin-1ß and osteogenic protein-1 decreased while tumor necrosis factor alpha and
transforming growth factor beta increased
TIMP-3 protein levels ; however, TIMP-3 mRNA was not significantly affected by any of these treatments
Leco et al., J Biol Chem 1994
:
Like TIMP-1,
TIMP-3 was highly
inducible in mouse C3H 10T1/2 fibroblasts by phorbol ester ( PMA ), epidermal growth factor (EGF), and
transforming growth factor-beta 1 , but nuclear run-on assays showed that the on/off transcription kinetics were faster for TIMP-3 than TIMP-1
Gatsios et al., Eur J Biochem 1996
:
We found that
transforming growth factor beta 1 as well as interleukin-1 beta
induce gene expression of both TIMP-1 and
TIMP-3
Su et al., DNA Cell Biol 1996
(Osteoarthritis) :
Regulation of
tissue inhibitor of metalloproteinases-3 gene expression by
transforming growth factor-beta and dexamethasone in bovine and human articular chondrocytes
Mattila et al., J Invest Dermatol 1998
(Scleroderma, Localized) :
Specific activation of TIMP-3 gene expression in scleroderma skin fibroblasts in culture and in vivo suggests a role for TIMP-3 in the pathogenesis of dermal fibrosis via inhibition of turnover of fibrotic dermal extracellular matrix, possibly due to
upregulation of
TIMP-3 expression by
transforming growth factor-beta
Huang et al., J Clin Endocrinol Metab 1998
:
We have investigated the
roles of IL-1 beta and
transforming growth factor-beta ( TGF beta ) in regulating TIMP-1,
TIMP-3 , and 92-kDa type IV collagenase messenger ribonucleic acid ( mRNA ) expression in human endometrial stromal cells using quantitative competitive PCR
Fabunmi et al., Circ Res 1998
(Arteriosclerosis) :
Human smooth muscle cells constitutively expressed TIMP-1, -2 and -3 proteins ; platelet derived growth factor and
transforming growth factor-beta augmented levels of TIMP-1 and
TIMP-3 but not TIMP-2