◀ Back to C3
C3 — TNF
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
C3
→
TNF
(increases)
Evidence: In contrast to the pattern for effect of IL-4 on factor B synthesis, the TNF-induced rate of synthesis of C3 was augmented by IL-4.
Text-mined interactions from Literome
Matata et al., Ann Thorac Surg 2000
(Inflammation) :
Complement C3a and elastase levels were rapidly increased upon the institution of CPB, and this was
followed by increases in IL-8,
TNF-alpha , and sE-selectin
Ogle et al., Cytokine 1990
:
The cytokines
tumor necrosis factor alpha (TNF alpha) , granulocyte-macrophage colony stimulating factor ( GM-CSF ), granulocyte colony stimulating factor ( G-CSF ), and interleukin 1 (IL 1) all
caused an upregulation of
C3b receptors ( CR1 ) on neutrophils that ranged from around 76 % ( G-CSF and IL 1 ) to 93 % ( TNF alpha and GM-CSF ) of the upregulation obtained by pretreatment of the neutrophils with the chemotactic peptide FMLP
Livingston et al., J Surg Res 1989
:
TNF 1 unit/ml
increased phagocytosis ( 666 +/- 47 vs 542 +/- 19 ), respiratory burst ( 326 +/- 33 vs 258 +/- 17 ), and
C3b ( 374 +/- 42 vs 157 +/- 14 ; all P less than 0.05 ) over those of control