Gene interactions and pathways from curated databases and text-mining

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C3 — TNF

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: C3 → TNF (increases)
    Evidence: In contrast to the pattern for effect of IL-4 on factor B synthesis, the TNF-induced rate of synthesis of C3 was augmented by IL-4.

Text-mined interactions from Literome

Matata et al., Ann Thorac Surg 2000 (Inflammation) : Complement C3a and elastase levels were rapidly increased upon the institution of CPB, and this was followed by increases in IL-8, TNF-alpha , and sE-selectin
Ogle et al., Cytokine 1990 : The cytokines tumor necrosis factor alpha (TNF alpha) , granulocyte-macrophage colony stimulating factor ( GM-CSF ), granulocyte colony stimulating factor ( G-CSF ), and interleukin 1 (IL 1) all caused an upregulation of C3b receptors ( CR1 ) on neutrophils that ranged from around 76 % ( G-CSF and IL 1 ) to 93 % ( TNF alpha and GM-CSF ) of the upregulation obtained by pretreatment of the neutrophils with the chemotactic peptide FMLP
Livingston et al., J Surg Res 1989 : TNF 1 unit/ml increased phagocytosis ( 666 +/- 47 vs 542 +/- 19 ), respiratory burst ( 326 +/- 33 vs 258 +/- 17 ), and C3b ( 374 +/- 42 vs 157 +/- 14 ; all P less than 0.05 ) over those of control