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CAPN2 — TNF

Text-mined interactions from Literome

Ishikawa et al., Biochem Biophys Res Commun 1999 (Arthritis, Rheumatoid...) : In RA FLS, although IL-6 did not alter m-calpain mRNA expression, IL-1 + tumor necrosis factor ( TNF ) and IL-1 + transforming growth factor ( TGF ) down-regulated m-calpain mRNA expression
Wang et al., J Hepatol 2001 (Reperfusion Injury) : Cytoprotective effect of prednisolone in hepatic IR injury was closely associated with suppression of IL-beta/TNF-alpha production and calpain mu activation
Zhao et al., J Neurosci Res 2001 : Results of this study suggest TNF-alpha may induce caspase-3 activation but not calpain activation in septo-hippocampal cultures and that this activation of caspase-3 at least partially contributes to TNF-alpha induced apoptosis
Coward et al., Clin Exp Allergy 2004 : The NF-kappaB inhibitors, calpain inhibitor 1 ( 10 microm ), pentoxifylline ( 0.5 mm ), pyrrolidine dithiocarbamate ( PDTC, 10 microm ) or gliotoxin ( 1 pg/mL ) reduced the generation of GM-CSF, TNF-alpha and IL-8 in parallel with their inhibition of NF-kappaB
Fushimi et al., Osteoarthritis Cartilage 2004 : Implication of prostaglandin E ( 2 ) in TNF-alpha induced release of m-calpain from HCS-2/8 chondrocytes ... TNF-alpha ( 10 ng/ml ) stimulated m-calpain release with transient increase in cellular m-calpain in HCS-2/8 cells ... AH6809, an EP1/2 antagonist, but not SC19220 ( an EP1 antagonist ), effectively inhibited TNF-alpha induced m-calpain release ... These results suggest that TNF-alpha stimulates upregulation and release of m-calpain in chondrocytic HCS-2/8 cells, and that stimulation of EP2-PGE ( 2 ) receptor by produced PGE ( 2 ) is deeply involved in this process
Morita et al., Biochem Biophys Res Commun 2006 (Arthritis, Rheumatoid) : Tumor necrosis factor ( TNF-alpha ) stimulation induced increased expression of mu-calpain, m-calpain , and MMP-3 in these cells, as well as the release of calpain and MMP-3 into the culture medium
Li et al., Cardiovasc Res 2009 (Disease Models, Animal...) : gp91(phox)-NADPH oxidase mediated calpain-1 activation induces caspase-3 activation and TNF-alpha expression in cardiomyocytes during LPS stimulation