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AKT1 — TNFRSF1A

Text-mined interactions from Literome

Ahn et al., Life Sci 2008 : Moreover, EGCG inhibited Akt phosphorylation as well as TNF activation of TNFR1 , which subsequently resulted in reduced MCP-1 production
Lee et al., J Cell Physiol 2010 (MAP Kinase Signaling System) : Taken together, these data suggest that in A549 cells, TNF-alpha induces MMP-9 expression via the TNFR1/TRAF2/PKCalpha dependent JNK1/2/c-Jun and c-Src/EGFR/PI3K/Akt pathways
Wang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2011 : MC3T3 cells were serum starved for 22 h, treated with MCD ( 10 g/L ) for 60 min followed by TNF-a ( 10 µg/L ) for 0, 5, 10, 15 or 30 min, or TNF-a plus CHX ( 10 mg/L ) for 4 h to induce apoptosis, then TNFR1 mediated I?Ba degradation, phosphorylation of AKT , ERK or p38, and processing of caspase-3 were analyzed by using SDS-PAGE/Western blotting method ... Reduction of MC3T3 cell surface cholesterol dramatically inhibited TNFR1 mediated AKT phosphorylation, while did not affect the degradation of I?Ba, activation of ERK or p38, and processing of caspase-3 induced by TNF-a ... Cholesterol depletion can destruct lipid rafts ; therefore our results suggest that lipid raft is essential for TNFR1 mediated AKT phosphorylation, but is dispensable for TNFR1 mediated degradation of I?Ba, activation of ERK or p38 and processing of caspase-3