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CD8A — TNFSF9
Text-mined interactions from Literome
Blazar et al., J Immunol 2001
(Graft vs Host Disease...) :
By quantifying graft-vs-host disease alloresponses in vivo, we demonstrate that both CD4 ( + ) and
CD8 ( + ) T cell mediated alloresponses are
regulated by
4-1BB/4-1BB ligand interactions to approximately the same extent
Cannons et al., J Immunol 2001
:
To compare CD4 vs
CD8 responses to
4-1BBL under similar conditions of antigenic stimulation, we performed MLRs with purified CD4 or CD8 responders from CD28 ( +/+ ) and CD28 ( -/- ) mice
Wen et al., J Immunol 2002
:
To further understand the role of 4-1BBL in human T cell responses, we compared human CD4 and
CD8 T cell
responses to transfected human
4-1BBL plus TCR mediated stimulation
Dawicki et al., J Immunol 2004
:
The
4-1BBL ( -/- ) and double knockout mice were similarly
impaired in the
CD8 T cell response, whereas OX40L ( -/- ) and double knockout mice were similarly impaired in the CD4 T cell response to both protein Ag and influenza virus
Fuse et al., J Immunol 2007
:
Thus,
4-1BBL deficiency significantly
affects the function, but not the number, of virus-specific
CD8 ( + ) T cells during gammaherpesvirus latency, and its absence results in an increased viral burden