Gene interactions and pathways from curated databases and text-mining

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CASP14 — TRAF2

Text-mined interactions from Literome

Hentze et al., Hepatology 2004 : CPT treatment completely abrogated the TNF induced NF-kappa B activation, and mRNA expression of the antiapoptotic factors TNF-receptor associated factor 2 , FLICE-inhibitory protein, and X-linked inhibitor of apoptosis protein was also inhibited by CPT. The caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) -fluoromethylketone ( zVAD-fmk ) and benzyloxycarbonyl-Asp ( OMe ) -Glu ( OMe ) -Val-Asp ( OMe ) -chloromethylketone ( zDEVD-fmk ), as well as depletion of intracellular ATP by fructose prevented CPT/TNF induced apoptosis
Conti et al., J Neurosurg 2005 (Brain Neoplasms...) : The authors investigated the expression of NF-kappaB, caspase 3, TRAF1, TRAF2, and TRAF associated NF-kappaB activator/TRAF interacting protein ( TANK/I-TRAF ), a regulator of TRAF activity, in human gliomas
Georgopoulos et al., Cell Death Differ 2006 (Urologic Neoplasms) : Thus, TRAF3 stabilization, JNK activation and caspase-9 induction define a novel pathway of CD40 mediated apoptosis in carcinoma cells