Gene interactions and pathways from curated databases and text-mining

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TLR4 — TRAF6

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Vivarelli et al., J Exp Med 2004 : Since TRAF2 and TRAF6 play important roles in CD40 signaling and TRAF6 plays an important role in TLR4 signaling, we examined the role of RIP in signaling via CD40 and TLR4
Zhang et al., Infect Immun 2005 (Pseudomonas Infections) : We also determined that MyD88, IRAK, TRAF6 , and Toll interacting protein (Tollip), but not TIRAP, were involved in the TLR mediated response to P. aeruginosa in HAECs
Loniewski et al., Mol Immunol 2007 : However, an essential role of TRAF6 in TLR4 signaling and cytokine production is slightly controversial
Leppert et al., J Immunol 2007 : The soluble variant surface glycoprotein of African trypanosomes is recognized by a macrophage scavenger receptor and induces I kappa B alpha degradation independently of TRAF6 mediated TLR signaling ... Activation of RAW 264.7 cells by sVSG following treatment of the cells with the TRAF6 inhibitory peptide DIVK resulted in enhanced NF-kappaB signaling, suggesting both that TRAF6 dependent TLR activation of the pathway alone is not required for signaling and that TLR pathway components may negatively regulate expression of sVSG induced signaling
Chen et al., Cell Signal 2008 : Syntenin negatively regulates TRAF6 mediated IL-1R/TLR4 signaling
Verstak et al., J Biol Chem 2009 (Bacterial Infections...) : We found that Mal and TRAF6 directly interact in response to TLR2 and TLR4 stimulation, although membrane localization is not necessary to facilitate interaction
Kar et al., Eur J Immunol 2011 (Inflammation...) : Analysis of upstream signaling events revealed that TLR 2/4 mediated MyD88 dependent participation of IL-1R activated kinase (IRAK)1, TNF receptor associated factor (TRAF)6 and TGFß activated kinase (TAK)1 is essential to induce cystatin mediated I?B kinase ( IKK ) /NF-?B activation in macrophages
Clark et al., Proc Natl Acad Sci U S A 2011 : Toll-like receptor ( TLR ) ligands that signal via TIR-domain containing adapter inducing IFNß ( TRIF ) activate the I?B kinase ( IKK ) -related kinases, TRAF associated NF?B activator ( TANK) binding kinase-1 (TBK1 ) and IKKe, which then phosphorylate IRF3 and induce the production of IFNß
Jono et al., PloS one 2012 (MAP Kinase Signaling System) : PKC? synergizes with TLR dependent TRAF6 signaling pathway to upregulate MUC5AC mucin via CARMA1
Inomata et al., Biochem Biophys Res Commun 2013 : Furthermore, Atg5 deficiency increased formation of the MyD88-TRAF6 signaling complex induced by TLR stimulation, and it enhanced activation of NF-?B signaling but not MAPKs and Akt