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IL4 — TYK2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TYK2 → IL4 (increases) Doucet et al., Oncogene 2000*
  Evidence: Finally, Tyk2, the fourth member of the JAK family, was found to be constitutively tyrosine-phosphorylated in these cells. However, IL-4 and IL-13 increased its phosphorylation level in lung myo®broblasts (Figure 2j), but not in normal cells, where both cytokines appear to slightly decrease its extent of phosphoryla- tion (Figure 2i).
• NCI Pathway Database IL12-mediated signaling events: IL12Rbeta1/TYK2 complex (IL12RB1-TYK2) → IL4 (IL4) (modification, collaborate) Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
  Evidence: mutant phenotype, assay, physical interaction, other species

Text-mined interactions from Literome

Subramaniam et al., Biochem Biophys Res Commun 1999 : Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells, interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3, Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Doucet et al., Oncogene 2000 (Lung Neoplasms...) : In addition to these pathways, in lung tumor myofibroblasts, IL-4 and IL-13 induced the phosphorylation of JAK3 and increased the phosphorylation of Tyk2
Millward-Sadler et al., Osteoarthritis Cartilage 2006 (Mechanotransduction, Cellular...) : No phosphorylation of STAT5 or STAT6 was detected in either normal or OA chondrocytes following mechanical stimulation ( MS ) IL4 stimulation resulted in a decrease in Tyk2 phosphorylation and an increase in phosphorylation of STAT6 in both normal and OA chondrocytes
Cho et al., Mol Immunol 2011 : Although IL-4 induced tyrosine phosphorylation of JAK1 and TYK2 , RNA interference experiments revealed that only JAK1 was responsible for the IL-4 stimulated STAT6 phosphorylation
Welham et al., J Biol Chem 1995 (Leukemia, Erythroblastic, Acute...) : Both IL-13 and IL-4 induced low levels of tyrosine phosphorylation of Tyk-2 and Jak-1
Murata et al., J Biol Chem 1995 (Colonic Neoplasms) : The phosphorylation of JAK1 and JAK2 was induced by IL-4 stimulation ; however, Tyk2 was constitutively phosphorylated, and IL-4 treatment further augmented this phosphorylation
Wang et al., J Immunol 1997 (Fibrosarcoma) : It has been shown that IL-4 induces the tyrosine phosphorylation of JAK1 and JAK3 in the majority of hemopoietic cell types, and JAK2 and TYK2 in several other types
Murata et al., Cell Immunol 1997 (Cell Transformation, Viral) : The phosphorylation level of Tyk2 was augmented at a low level in response to IL-13 and IL-4 in two of three cell lines ; however, IL-13 did not induce or augment phosphorylation of the other JAK kinases
Murata et al., Int Immunol 1998 : The Janus kinase (JAK)2 and Tyk2 were phosphorylated in response to IL-4 or IL-13 in sk559 and sk574 cell lines