Gene interactions and pathways from curated databases and text-mining

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CBL — VAV1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Miura-Shimura et al., J Biol Chem 2003 : Cbl mediated ubiquitinylation and negative regulation of Vav ... Interaction with Cbl also induced the loss of phosphorylated Vav
Marengère et al., J Immunol 1997 : The interaction between Vav and c-Cbl is directly mediated via the SH2 domain of Vav and is dependent on tyrosine phosphorylation of c-Cbl
Bustelo et al., Oncogene 1997 : By contrast, expression of truncated Cbl-b proteins and of missense mutants analogous to those found in inactive Sli-1 proteins have no detectable effect on Vav activity