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ITGAV — VTN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB5-VTN → TGFB1 (increases) Lai et al., J Biol Chem 2000
  Evidence: TGF-beta increased cell adhesion to vitronectin and up-regulated the surface level of alpha(v)beta(5) via increasing beta(5) protein synthesis by a transcriptional mechanism.
• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB5-VTN → TGFB1 (increases, TGFB1 Translocation) Lai et al., J Biol Chem 2000
  Evidence: TGF-beta increased cell adhesion to vitronectin and up-regulated the surface level of alpha(v)beta(5) via increasing beta(5) protein synthesis by a transcriptional mechanism.
• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB3-VTN → VEGFA (increases)
  Evidence: VEGF165 also influenced the interaction of HUVECs with the prototypic ligand for aVb3, vitronectin bFGF did augment cell migration onto vitronectin, almost as effectively as VEGF165. The bFGF-stimulated migration also was inhib- ited by c7E3 (data not shown). Thus, both major angio- genic growth factors enhanced HUVEC migration in an aVb3- dependent fashion.
• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB3 → VTN (increases, VTN Activity) Soldi et al., EMBO J 1999
  Evidence: Therefore, avb3 associates with the tyrosine-phosphorylated PDGF and insulin receptor (Vuori and Ruoslahti, 1994; Rousseau et al., 1997) and its natural ligand vitronectin enhances the biological activity of PDGF-b (Schneller et al., 1997;Woodard et al., 1998).
• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB3 → VTN (increases, VTN Activity) Giancotti et al., Science 1999
  Evidence: For example, avb3 associates with the PDGF receptor, and fibroblasts show greater proliferation in response to PDGFb when adhering to the avb3 ligand vitronectin than when they adhere to the b1 integrin ligand collagen (26).
• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB3-VTN → Complex of ITGAV-ITGB3 (directlyIncreases, ITGAV/ITGB3/VTN Activity)
  Evidence: VEGF165 also influenced the interaction of HUVECs with the prototypic ligand for aVb3, vitronectin bFGF did augment cell migration onto vitronectin, almost as effectively as VEGF165. The bFGF-stimulated migration also was inhib- ited by c7E3 (data not shown). Thus, both major angio- genic growth factors enhanced HUVEC migration in an aVb3- dependent fashion.
• OpenBEL Selventa BEL large corpus: ITGAV → Complex of ITGB5-VTN (directlyIncreases, ITGB5/VTN Activity)
  Evidence: PC5-antisense oligonucleotides and dec-CMK inhibited VSMC adhesion to the alpha(v)beta3/beta5 ligand vitronectin
• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB3-VTN → FGF2 (increases)
  Evidence: VEGF165 also influenced the interaction of HUVECs with the prototypic ligand for aVb3, vitronectin bFGF did augment cell migration onto vitronectin, almost as effectively as VEGF165. The bFGF-stimulated migration also was inhib- ited by c7E3 (data not shown). Thus, both major angio- genic growth factors enhanced HUVEC migration in an aVb3- dependent fashion.
• KEGG Focal adhesion: CHAD/COL11A1/COL11A2/COL1A1/COL1A2/COL2A1/COL3A1/COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/COL5A1/COL5A2/COL5A3/COL6A1/COL6A2/COL6A3/COL6A6/COMP/FN1/IBSP/LAMA1/LAMA2/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/LAMB4/LAMC1/LAMC2/LAMC3/RELN/SPP1/THBS1/THBS2/THBS3/THBS4/TNC/TNN/TNR/TNXB/VTN/VWF → Complex of 21 proteins (protein-protein, activation)
• KEGG ECM-receptor interaction: VTN → Complex of ITGAV-ITGB1 (protein-protein, activation)
• KEGG ECM-receptor interaction: VTN → Complex of ITGAV-ITGB3 (protein-protein, activation)
• KEGG ECM-receptor interaction: VTN → Complex of ITGAV-ITGB5 (protein-protein, activation)
• KEGG ECM-receptor interaction: VTN → Complex of ITGAV-ITGB8 (protein-protein, activation)
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: Hsp90 (HSP90AA1) → alphav/beta3 Integrin/Vitronectin complex (VTN-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: Hsp90 (HSP90AA1) → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: alphav/beta3 Integrin/Vitronectin complex (VTN-ITGAV-ITGB3) → VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) (modification, collaborate)
  Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: alphav/beta3 Integrin/Vitronectin complex (VTN-ITGAV-ITGB3) → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Rousseau et al., J Biol Chem 2000, Borges et al., J Biol Chem 2000, Masson-Gadais et al., Cell Stress Chaperones 2003, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer)/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-VTN-ITGAV-ITGB3) → Src (SRC) (modification, activates) Le Boeuf et al., J Biol Chem 2004
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) → PAI-1 (SERPINE1) (modification, collaborate) Czekay et al., J Cell Biol 2003
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) → uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3) (modification, collaborate)
  Czekay et al., J Cell Biol 2003
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Czekay et al., J Cell Biol 2003
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Czekay et al., J Cell Biol 2003
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin complex (PLAUR-PLAU-ITGAV-ITGB3) → uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) (modification, collaborate)
  Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Degryse et al., J Biol Chem 2005, Salasznyk et al., Matrix Biol 2007, Wei et al., Nat Med 2008
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin complex (PLAUR-PLAU-ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Degryse et al., J Biol Chem 2005, Salasznyk et al., Matrix Biol 2007, Wei et al., Nat Med 2008
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Degryse et al., J Biol Chem 2005, Salasznyk et al., Matrix Biol 2007, Wei et al., Nat Med 2008
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta5 Integrin complex (PLAUR-PLAU-ITGAV-ITGB5) → uPA/uPAR/alphav/beta5 Integrin/Vitronectin complex (PLAUR-VTN-PLAU) (modification, collaborate)
  Carriero et al., Cancer Res 1999, Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Franco et al., J Cell Sci 2006, Yebra et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta5 Integrin complex (PLAUR-PLAU-ITGAV-ITGB5) → Vitronectin (VTN) (modification, collaborate) Carriero et al., Cancer Res 1999, Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Franco et al., J Cell Sci 2006, Yebra et al., J Biol Chem 1996
  Evidence: assay, physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: alphav/beta5 Integrin/Vitronectin complex (VTN-ITGAV-ITGB5) → alphav/beta5 Integrin complex (ITGAV-ITGB5) (modification, collaborate)
  Smith et al., J Biol Chem 1990, Rowland et al., Stem Cells Dev 2010*, Kim et al., J Biol Chem 1994*, Fernández-Ruiz et al., Cytogenet Cell Genet 1993*, Stuiver et al., J Cell Physiol 1996, Memmo et al., J Cell Sci 1998*
  Evidence: physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: alphav/beta5 Integrin/Vitronectin complex (VTN-ITGAV-ITGB5) → Vitronectin (VTN) (modification, collaborate) Smith et al., J Biol Chem 1990, Rowland et al., Stem Cells Dev 2010*, Kim et al., J Biol Chem 1994*, Fernández-Ruiz et al., Cytogenet Cell Genet 1993*, Stuiver et al., J Cell Physiol 1996, Memmo et al., J Cell Sci 1998*
  Evidence: physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: alphav/beta5 Integrin complex (ITGAV-ITGB5) → Vitronectin (VTN) (modification, collaborate) Smith et al., J Biol Chem 1990, Rowland et al., Stem Cells Dev 2010*, Kim et al., J Biol Chem 1994*, Fernández-Ruiz et al., Cytogenet Cell Genet 1993*, Stuiver et al., J Cell Physiol 1996, Memmo et al., J Cell Sci 1998*
  Evidence: physical interaction
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin complex (ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin complex (ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Naik et al., J Cell Sci 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: uPA/uPAR/alphav/beta5 Integrin complex (PLAUR-PLAU-ITGAV-ITGB5) → uPA/uPAR/alphav/beta5 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB5) (modification, collaborate)
  Carriero et al., Cancer Res 1999, Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Franco et al., J Cell Sci 2006, Yebra et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: uPA/uPAR/alphav/beta5 Integrin complex (PLAUR-PLAU-ITGAV-ITGB5) → Vitronectin (VTN) (modification, collaborate) Carriero et al., Cancer Res 1999, Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Franco et al., J Cell Sci 2006, Yebra et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: uPA/uPAR/alphav/beta5 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB5) → Vitronectin (VTN) (modification, collaborate) Carriero et al., Cancer Res 1999, Wilcox-Adelman et al., Cell adhesion and communication 2000, Czekay et al., J Cell Biol 2003, Franco et al., J Cell Sci 2006, Yebra et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin complex (ITGAV-ITGB3) → Vitronectin (VTN) (modification, activates) Cruet-Hennequart et al., Oncogene 2003*
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin complex (ITGAV-ITGB3) → Vitronectin (VTN) (modification, activates) Paulhe et al., Biochem Biophys Res Commun 2002*
  Evidence: assay
• NCI Pathway Database Beta1 integrin cell surface interactions: alphav/beta1 Integrin/Vitronectin complex (VTN-ITGAV-ITGB1) → alphav/beta1 Integrin complex (ITGAV-ITGB1) (modification, collaborate)
  Bodary et al., J Biol Chem 1990*, Kirchhofer et al., J Biol Chem 1991, Vogel et al., J Biol Chem 1990, Marshall et al., J Cell Sci 1995*
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alphav/beta1 Integrin/Vitronectin complex (VTN-ITGAV-ITGB1) → Vitronectin (VTN) (modification, collaborate) Bodary et al., J Biol Chem 1990*, Kirchhofer et al., J Biol Chem 1991, Vogel et al., J Biol Chem 1990, Marshall et al., J Cell Sci 1995*
  Evidence: physical interaction
• NCI Pathway Database Beta1 integrin cell surface interactions: alphav/beta1 Integrin complex (ITGAV-ITGB1) → Vitronectin (VTN) (modification, collaborate) Bodary et al., J Biol Chem 1990*, Kirchhofer et al., J Biol Chem 1991, Vogel et al., J Biol Chem 1990, Marshall et al., J Cell Sci 1995*
  Evidence: physical interaction
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin complex (ITGAV-ITGB3) → Vitronectin (VTN) (modification, activates) Persad et al., J Biol Chem 2001, Cruet-Hennequart et al., Oncogene 2003*
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: None → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Le Boeuf et al., J Biol Chem 2004
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: RHOA/GDP complex (RHOA) → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Le Boeuf et al., J Biol Chem 2004
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer)/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-VTN-ITGAV-ITGB3) → alphav/beta3 Integrin/Vitronectin complex (VTN-ITGAV-ITGB3) (modification, collaborate)
  Le Boeuf et al., J Biol Chem 2004
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer)/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-VTN-ITGAV-ITGB3) → VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) (modification, collaborate)
  Le Boeuf et al., J Biol Chem 2004
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: alphav/beta3 Integrin/Vitronectin complex (VTN-ITGAV-ITGB3) → VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) (modification, collaborate)
  Le Boeuf et al., J Biol Chem 2004
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin/CK2/Nucleolin complex (PLAUR-VTN-NCL-PLAU-ITGAV-ITGB3) → uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) (modification, collaborate)
  Dumler et al., Curr Biol 1999, Stepanova et al., J Biol Chem 2002
  Evidence: assay, physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin/CK2/Nucleolin complex (PLAUR-VTN-NCL-PLAU-ITGAV-ITGB3) → Nucleolin (NCL) (modification, collaborate) Dumler et al., Curr Biol 1999, Stepanova et al., J Biol Chem 2002
  Evidence: assay, physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) → Nucleolin (NCL) (modification, collaborate) Dumler et al., Curr Biol 1999, Stepanova et al., J Biol Chem 2002
  Evidence: assay, physical interaction
• NCI Pathway Database Beta3 integrin cell surface interactions: alphav/beta3 Integrin complex (ITGAV-ITGB3) → alphav/beta3 Integrin/Vitronectin complex (VTN-ITGAV-ITGB3) (modification, collaborate)
  Kirchhofer et al., J Biol Chem 1991, Kieffer et al., J Cell Biol 1991, Leavesley et al., J Cell Biol 1993*, Stuiver et al., J Cell Physiol 1996
  Evidence: physical interaction
• NCI Pathway Database Beta3 integrin cell surface interactions: alphav/beta3 Integrin complex (ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Kirchhofer et al., J Biol Chem 1991, Kieffer et al., J Cell Biol 1991, Leavesley et al., J Cell Biol 1993*, Stuiver et al., J Cell Physiol 1996
  Evidence: physical interaction
• NCI Pathway Database Beta3 integrin cell surface interactions: alphav/beta3 Integrin/Vitronectin complex (VTN-ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Kirchhofer et al., J Biol Chem 1991, Kieffer et al., J Cell Biol 1991, Leavesley et al., J Cell Biol 1993*, Stuiver et al., J Cell Physiol 1996
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta5 Integrin/Vitronectin complex (PLAUR-VTN-PLAU) → uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5) (modification, collaborate)
  Czekay et al., J Cell Biol 2003
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5) → Vitronectin (VTN) (modification, collaborate) Czekay et al., J Cell Biol 2003
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3) → Src (SRC) (modification, activates) Degryse et al., Blood 1999, Kjøller et al., J Cell Biol 2001, Liu et al., Exp Cell Res 2008, Smith et al., J Cell Biol 2008
  Evidence: mutant phenotype, assay
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: alphav/beta8 Integrin/Vitronectin complex (VTN-ITGAV-ITGB8) → alphav/beta8 Integrin complex (ITGAV-ITGB8) (modification, collaborate)
  Milner et al., J Cell Sci 1999*, Cambier et al., Cancer Res 2000*, Lakhe-Reddy et al., J Biol Chem 2006*, Moyle et al., J Biol Chem 1991, Nishimura et al., J Biol Chem 1994*
  Evidence: physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: alphav/beta8 Integrin/Vitronectin complex (VTN-ITGAV-ITGB8) → Vitronectin (VTN) (modification, collaborate) Milner et al., J Cell Sci 1999*, Cambier et al., Cancer Res 2000*, Lakhe-Reddy et al., J Biol Chem 2006*, Moyle et al., J Biol Chem 1991, Nishimura et al., J Biol Chem 1994*
  Evidence: physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: alphav/beta8 Integrin complex (ITGAV-ITGB8) → Vitronectin (VTN) (modification, collaborate) Milner et al., J Cell Sci 1999*, Cambier et al., Cancer Res 2000*, Lakhe-Reddy et al., J Biol Chem 2006*, Moyle et al., J Biol Chem 1991, Nishimura et al., J Biol Chem 1994*
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: pro-uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAU-PLAUR-VTN-ITGAV-ITGB3) → pro-uPA/uPAR/alphav/beta3 Integrin complex (PLAU-PLAUR-ITGAV-ITGB3) (modification, collaborate)
  Degryse et al., Oncogene 2001
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: pro-uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAU-PLAUR-VTN-ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Degryse et al., Oncogene 2001
  Evidence: physical interaction
• NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: pro-uPA/uPAR/alphav/beta3 Integrin complex (PLAU-PLAUR-ITGAV-ITGB3) → Vitronectin (VTN) (modification, collaborate) Degryse et al., Oncogene 2001
  Evidence: physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: alphav/beta6 Integrin/Vitronectin complex (VTN-ITGAV-ITGB6) → alphav/beta6 Integrin complex (ITGAV-ITGB6) (modification, collaborate)
  Huang et al., J Cell Sci 1998*
  Evidence: physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: alphav/beta6 Integrin/Vitronectin complex (VTN-ITGAV-ITGB6) → Vitronectin (VTN) (modification, collaborate) Huang et al., J Cell Sci 1998*
  Evidence: physical interaction
• NCI Pathway Database Beta5 beta6 beta7 and beta8 integrin cell surface interactions: alphav/beta6 Integrin complex (ITGAV-ITGB6) → Vitronectin (VTN) (modification, collaborate) Huang et al., J Cell Sci 1998*
  Evidence: physical interaction
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin complex (ITGAV-ITGB3) → Vitronectin (VTN) (modification, activates) Paulhe et al., J Biol Chem 2001
  Evidence: assay, physical interaction
• Reactome Reaction: ITGAV → VTN (reaction) Nakamura et al., J Bone Miner Metab 2007*, Pytela et al., Proc Natl Acad Sci U S A 1985*, Pytela et al., Science 1986*, Nishimura et al., J Biol Chem 1994*, Marshall et al., J Cell Sci 1995*, Schnapp et al., J Biol Chem 1995, Panetti et al., J Biol Chem 1993*, Horton et al., Int J Biochem Cell Biol 1997*, Memmo et al., J Cell Sci 1998*
• Reactome Reaction: ITGAV → VTN (indirect_complex) Nakamura et al., J Bone Miner Metab 2007*, Pytela et al., Proc Natl Acad Sci U S A 1985*, Pytela et al., Science 1986*, Nishimura et al., J Biol Chem 1994*, Marshall et al., J Cell Sci 1995*, Schnapp et al., J Biol Chem 1995, Panetti et al., J Biol Chem 1993*, Horton et al., Int J Biochem Cell Biol 1997*, Memmo et al., J Cell Sci 1998*
• WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: COL4A2/CHAD/TNR/COL11A2/LAMB3/COMP/COL1A2/FN1/THBS2/COL5A1/RELN/LAMC3/LAMC2/LAMB1/COL4A6/TNC/COL5A2/LAMA4/COL4A1/LAMA3/LAMC1/LAMB2/THBS4/COL2A1/THBS3/LAMA5/IBSP/COL6A2/VWF/TNXB/TNN/SPP1/LAMA2/COL3A1/LAMA1/VTN/THBS1/COL1A1/COL11A1/COL5A3/COL4A4 → ITGA5/ITGAE/ITGAX/ITGAD/ITGA7/ITGA2B/ITGA9/ITGA2/PELO/ITGA3/ITGA8/ITGA10/ITGAV/ITGA6/ITGAL/ITGA4/ITGA11 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM ITGB3-ITGAV-VTN complex: ITGB3-ITGAV-VTN complex complex (ITGAV-ITGB3-VTN) Zheng et al., J Biol Chem 2000*
• MIPS CORUM ITGB5-ITGAV-VTN complex: ITGB5-ITGAV-VTN complex complex (ITGAV-ITGB5-VTN) Smith et al., J Biol Chem 1990
• IRef Corum Interaction: Complex of ITGAV-VTN-ITGB5-VTN-ITGAV-ITGB5 (association, coimmunoprecipitation) Smith et al., J Biol Chem 1990
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Smith et al., J Biol Chem 1990
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Zheng et al., J Biol Chem 2000*
• IRef Hprd Interaction: Complex of VTN-VTN-ITGAV-ITGB6-ITGB6-ITGAV-ITGAV-VTN-ITGB6 (in vivo) Weinacker et al., J Biol Chem 1994
• IRef Intact Interaction: Complex of ITGAV-ITGB3-VTN-ITGB3-VTN-ITGAV (physical association, solid phase assay) Smith et al., J Biol Chem 1990

Text-mined interactions from Literome

Kappert et al., Basic Res Cardiol 2001 : In contrast, the alphavbeta3 integrin did not contribute to the adhesion and spreading on fibronectin, vitronectin , gelatin or collagen I coated layers
Miceli et al., Invest Ophthalmol Vis Sci 1997 : Vitronectin is the component responsible for serum stimulation of ROS uptake, and this uptake appears to be mediated by an alpha v beta 5 integrin
Perry et al., Am J Respir Cell Mol Biol 1997 : Nonimmune phagocytosis of liposomes by rat alveolar macrophages is enhanced by vitronectin and is vitronectin-receptor mediated