Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Gaugel et al., Journal of molecular signaling 2012 : Both, downregulation of mTOR by siRNA or cellular PtdIns ( 3 ) P elevation upon PIKfyve inhibition by YM201636 significantly increased the localization of WIPI-1 at autophagosomal membranes
Ho et al., J Biol Chem 2011 : In this study, we determined that WIPI1 , an ATG18 homologue that is shown to localize to both autophagosomes and early endosomes, inhibited mammalian target of rapamycin (MTOR) signaling, leading to increased transcription of melanogenic enzymes and the formation of mature melanosomes