Gene interactions and pathways from curated databases and text-mining

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PCNA — XIC

Text-mined interactions from Literome

Chuang et al., J Biol Chem 2005 : Our studies also indicate that Xic1 degradation is absolutely dependent upon the binding of Xic1 to PCNA in both Xenopus egg and gastrulation stage extracts
Zhu et al., Cell division 2013 : Our studies indicated that following primer synthesis during the initiation of DNA replication, Xic2 is targeted for DNA- and PCNA dependent ubiquitin mediated proteolysis and that Cdt2 can promote Xic2 turnover
Su et al., Proc Natl Acad Sci U S A 1995 : We have isolated a gene encoding Xic-1 , a 27-kDa cyclin dependent kinase (Cdk) inhibitor from Xenopus ovary that shares significant homology with both mammalian CIP1 and Kip1/Kip2 ... Truncation of the N terminus of Xic-1 increases the IC50 value for cyclin A/Cdk2 50-fold with no effect on the inhibition of cyclin E/Cdk2 or cyclin B/Cdc2.Xic-1 inhibits both single stranded and nuclear DNA synthesis in egg extracts, an effect reversed by proliferating cell nuclear antigen or cyclin E/Cdk2, respectively