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IL1B — RAC1

Text-mined interactions from Literome

Finder et al., Am J Physiol Lung Cell Mol Physiol 2001 (MAP Kinase Signaling System) : In this study, overexpression of constitutively active Rac1 or its dominant negative mutant did not affect IL-1beta induction of iNOS
Schotte et al., J Biol Chem 2004 : Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1 mediated maturation and release of interleukin-1beta
Kuijk et al., Blood 2008 (Mevalonate Kinase Deficiency) : Here we show that inhibition of HMG-CoA reductase by simvastatin treatment, mimicking MKD, results in increased IL-1beta secretion in a Rac1/PI3K dependent manner ... The small GTPase Rac1 was activated by simvastatin, and this was required for both PKB activation and IL-1beta secretion ... Importantly, inhibition of Rac1 in peripheral blood mononuclear cells isolated from MKD patients resulted in a dramatic reduction in IL-1beta release
Nishida et al., J Biol Chem 2010 : PTX induced biphasic increases in Rac activity, and the Rac activation in a late but not an early phase was suppressed by IL-1beta siRNA, suggesting that IL-1beta induced Rac activation contributes to the amplification of Rac dependent signaling induced by PTX