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PARP1 — PRKAG1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Walker et al., Biochem Biophys Res Commun 2006
:
The aim of this study was to examine the
role of
AMPK in modulating poly ( ADP-ribose ) polymerase (
PARP ), a nuclear enzyme involved in maintaining chromatin structure and DNA repair ... These data suggest a novel
role for
AMPK in regulating
PARP activity through a direct interaction involving phosphorylation
Li et al., Neurosci Lett 2010
(Stroke) :
PolyADP ribose polymerase ( PARP ) , a key mediator of ischemic cell death,
stimulates AMPK activation, yet activation of PARP appears to be selectively detrimental in male brain
Son et al., Toxicol Appl Pharmacol 2011
:
Consequently, these results suggest that cadmium mediated ROS generation causes
PARP activation and energy depletion, and eventually
induces autophagy through the activation of
LKB1-AMPK signaling and the down-regulation of mTOR in skin epidermal cells