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IL2 — IL21

Text-mined interactions from Literome

Liu et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 1997 (Yang Deficiency) : Hemorheological indexes, brain noradrenaline ( NE ), adrenocorticotropine ( ACTH ), beta endorphin, cortisol, estradiol, testosterone, interleukin-II (IL-2), tumour necrosis factor (TNF) in the blood, and rat spleen 's lymphocyte transformation and induction of IL-2 and the activity of natural killer cells ( NKC )
Song et al., Neuroscience 1999 : As well, interleukin-6 and interleukin-2 were both found to reduce the homovanillic acid response associated with the stress, and interleukin-2 promoted a decline of homovanillic acid levels
Greene et al., Biochim Biophys Acta 1999 : Interleukin-1 receptor associated kinase and TRAF-6 mediate the transcriptional regulation of interleukin-2 by interleukin-1 via NFkappaB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA
Matsuura et al., Dig Liver Dis 2000 (Crohn Disease) : The effect of interleukin-4 on lamina propria mononuclear cells from Crohn 's disease, ulcerative colitis and control mucosa was assessed on various T-cell functions : interleukin-2 induced cytotoxicity, soluble interleukin-2 receptor and interleukin-2 production, and expression of mRNA for interleukin-2R and interferon-gamma
Kelley et al., Lipids 2001 : CLA supplementation did not alter the in vitro secretion of prostaglandin E2, leukotriene B4, interleukin-1beta (IL-1beta), or tumor necrosis factor alpha (TNFalpha) by PBMC simulated with lipopolysaccharide, and the secretion of IL-2 by PBMC stimulated with phytohemagglutinin
Dalhoff et al., Lancet Infect Dis 2003 : In general, most fluoroquinolone derivatives superinduce in-vitro interleukin 2 synthesis but inhibit synthesis of interleukin 1 and tumour necrosis factor (TNF)alpha ; furthermore, they enhance significantly the synthesis of colony stimulating factors (CSF)
Baan et al., Transplantation 2007 : Interestingly, induction of IL-21 was highly dependent on IL-2 ( as in the presence of anti-IL-2, anti-IL-2R alpha-chain, and the immunosuppressive drugs cyclosporine A, tacrolimus, and rapamycin ) the transcription of IL-21 was almost completely inhibited, whereas in the presence of exogenous IL-2 the mRNA expression of IL-21 was even more upregulated
Fernández et al., Appl Environ Microbiol 2007 : Furthermore, expression of a mature mouse IL-2 gene resulted in interleukin secretion without the requirement for a leader sequence
Hinrichs et al., Blood 2008 : Furthermore, IL-21 repressed expression of IL-2Ra and inhibited IL-2 mediated acquisition of a cytolytic CD8 ( + ) T-cell phenotype
Lindemann et al., J Biol Chem 2008 : Moreover, similar to the mutant EPO-IL-2Rbeta chimera, IL-15 and IL-21 induced IL-17RA preferentially compared with IL-2, and IL-2 but not IL-15 or IL-21 mediated prolonged activation of the PI3K p85 regulatory subunit
Tomizawa et al., Clin Exp Immunol 1991 : Of the cytokines studied, interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) were involved in the regulation of IL-2R on B cells
Nakayamada et al., Immunity 2011 : Herein, we showed interleukin-12 acting via the transcription factor STAT4 induced both Il21 and Bcl6 genes, generating cells with features of both Tfh and Th1 cells
Cheng et al., Zhonghua Zhong Liu Za Zhi 2011 (Carcinoma, Hepatocellular...) : In addition, the plasmid pIRES-GM-CSF-IL-21 can also promote the secretion of IFN-? and IL-2 in vivo, and enhance the cytotoxic activity of splenic NK and CTLs against the transplanted liver tumor
Attridge et al., Blood 2012 : IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis
Jin et al., J Autoimmun 2013 (Inflammation) : IL-6 induces IL-21 production in CD4 T cells and IL-10 inducing effect of IL-6 requires both IL-21 and IL-2
Scholz et al., Cell Signal 1989 (Leukemia) : Synergistic induction of interleukin 2 receptor ( TAC ) expression on YT cells by interleukin 1 or tumor necrosis factor alpha in combination with cAMP inducing agents
Schultzberg et al., Neuroscience 1989 : These antisera also inhibited stimulation of interleukin-2 receptor expression by purified human interleukin-1
Falk et al., Lymphokine Res 1989 : The cytokine interleukin-1 plays an important role in the induction of IL-2 secretion and IL-2 receptor expression
Lee et al., J Rheumatol 1985 (Arthritis...) : The low IL-2 levels was not a result of degradation or consumption of endogenously produced interleukin
Anastassakos et al., Clin Exp Immunol 1987 (Chronic Disease...) : To test the hypothesis that reduced lymphocyte transformation in response to PHA in chronic hepatitis B virus infection might be due to deficient lymphokine production, lymphocyte transformation was measured in the presence or absence of exogenous interleukin 1, interleukin 2 or both, or, as a source of mixed lymphokines, supernatants from mixed lymphocyte reactions
Uchiyama et al., Microbiol Immunol 1986 : T cells obtained by the nylon wool column method alone produced IL 2 on TSST-1 stimulation in the presence of either macrophages or a macrophage lysate containing interleukin 1
Mukaida et al., J Immunol 1987 (Leukemia) : Signal requirement for interleukin-1 dependent interleukin 2 production by a human leukemia derived HSB.2 subclone
Soulillou et al., Eur J Cancer Clin Oncol 1985 (Hodgkin Disease) : Peripheral blood lymphocytes ( PBL ) of patients with Hodgkin 's disease were studied for their capacity to produce interleukin 2 upon in vitro phytohemaglutinin stimulation in the presence or absence of either interleukin 1 or indomethacin ( 2 micrograms/ml ) ; eight patients were studied at the discovery of their disease before receiving any therapy ( onset HD ; OHD )
Solbach et al., Blood 1984 (Sezary Syndrome) : In this article we have studied the effects of the immunosuppressive drug cyclosporine A ( CsA ) on growth, interleukin-2 (IL-2) production, and the induction of IL-2 responsiveness of peripheral blood monocytes ( PBMs ) from five patients with Sézary 's syndrome in vitro, using the lectin phytohemagglutinin ( PHA ) and the phorbol ester phorbol myristate acetate ( PMA ) as stimuli
Knop et al., Hautarzt 1984 (Dermatitis, Atopic...) : The production of interleukin 2 is induced by interleukin 1, which can be also produced by keratinocytes ( epidermal T-cell activating factor, ETAF )
Bunjes et al., Eur J Immunol 1981 : The selective effects included a blockade of interleukin 2 release from activated T helper cells on the one hand and inhibition of interleukin 1 release from splenic adherent cells on the other
Hersey et al., J Immunol 1983 (Cell Transformation, Neoplastic...) : These supernatants did not inhibit interleukin 1 production, and also did not inhibit the mitogenic activity of performed IL 2 on IL 2-dependent target cells
Okada et al., Proc Natl Acad Sci U S A 1981 : In a clone ( 38-B ) that did not show any IL-2 activity in culture supernatants, the addition of macrophages induced IL-2 production in the presence of phytohemagglutinin, suggesting that interleukin-1 induced IL-2 production in T hybrid cells
Kees et al., J Immunol Methods 1994 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : A new human cell line for the molecular dissection of the requirement for interleukin-1 in the production of interleukin-2 by immature T cells
Armant et al., Eur J Immunol 1996 : Functional CD40 ligand expression on T lymphocytes in the absence of T cell receptor engagement : involvement in interleukin-2 induced interleukin-12 and interferon-gamma production