Description: Homo sapiens casein kinase 2, beta polypeptide (CSNK2B), mRNA. RefSeq Summary (NM_001320): This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]. Transcript (Including UTRs) Position: hg19 chr6:31,633,657-31,637,843 Size: 4,187 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr6:31,634,609-31,637,703 Size: 3,095 Coding Exon Count: 6
ID:CSK2B_HUMAN DESCRIPTION: RecName: Full=Casein kinase II subunit beta; Short=CK II beta; AltName: Full=Phosvitin; AltName: Full=Protein G5a; FUNCTION: Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit. SUBUNIT: Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. INTERACTION: Self; NbExp=6; IntAct=EBI-348169, EBI-348169; O00257-3:CBX4; NbExp=2; IntAct=EBI-348169, EBI-4392727; P68400:CSNK2A1; NbExp=10; IntAct=EBI-348169, EBI-347804; P19784:CSNK2A2; NbExp=4; IntAct=EBI-348169, EBI-347451; PTM: Phosphorylated by alpha subunit. SIMILARITY: Belongs to the casein kinase 2 subunit beta family. SEQUENCE CAUTION: Sequence=CAI18393.2; Type=Erroneous initiation;
Lupus Erythematosus, Systemic Geoffrey Hom et al. The New England journal of medicine 2008, Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX., The New England journal of medicine.
[PubMed 18204098]
We identified and then confirmed through replication two new genetic loci for SLE: a promoter-region allele associated with reduced expression of BLK and increased expression of C8orf13 and variants in the ITGAM-ITGAX region.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P67870
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
