Description: Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 (SLC25A31), nuclear gene encoding mitochondrial protein, mRNA. RefSeq Summary (NM_031291): The protein encoded by this gene is a member of the ADP/ATP carrier family of proteins that exchange cytosolic ADP for matrix ATP in the mitochondria. Cells over-expressing this gene have been shown to display an anti-apoptotic phenotype. This protein is also thought to play a role in spermatogenesis, where it is believed to associate with a part of the flagellar cytoskeleton and with glycolytic enzymes. Male mice with mutations in the mouse ortholog of this gene are sterile and spermatocytes display an early meiotic arrest phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]. Transcript (Including UTRs) Position: hg19 chr4:128,651,555-128,695,447 Size: 43,893 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr4:128,651,701-128,694,729 Size: 43,029 Coding Exon Count: 6
ID:ADT4_HUMAN DESCRIPTION: RecName: Full=ADP/ATP translocase 4; AltName: Full=ADP,ATP carrier protein 4; AltName: Full=Adenine nucleotide translocator 4; Short=ANT 4; AltName: Full=Solute carrier family 25 member 31; AltName: Full=Sperm flagellar energy carrier protein; FUNCTION: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum. Note=In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial region. TISSUE SPECIFICITY: Expressed in brain, liver, sperm and testis. SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 3 Solcar repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H0C2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
