Description: Homo sapiens chemokine (C motif) ligand 1 (XCL1), mRNA. RefSeq Summary (NM_002995): This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]. Transcript (Including UTRs) Position: hg19 chr1:168,545,711-168,551,315 Size: 5,605 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr1:168,545,876-168,550,458 Size: 4,583 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P47992
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001916 positive regulation of T cell mediated cytotoxicity GO:0002548 monocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0002725 negative regulation of T cell cytokine production GO:0002726 positive regulation of T cell cytokine production GO:0002826 negative regulation of T-helper 1 type immune response GO:0006935 chemotaxis GO:0006955 immune response GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007267 cell-cell signaling GO:0009615 response to virus GO:0010469 regulation of receptor activity GO:0010820 positive regulation of T cell chemotaxis GO:0030593 neutrophil chemotaxis GO:0031640 killing of cells of other organism GO:0032689 negative regulation of interferon-gamma production GO:0032703 negative regulation of interleukin-2 production GO:0032733 positive regulation of interleukin-10 production GO:0035782 mature natural killer cell chemotaxis GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043547 positive regulation of GTPase activity GO:0045892 negative regulation of transcription, DNA-templated GO:0050727 regulation of inflammatory response GO:0051209 release of sequestered calcium ion into cytosol GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO:0070098 chemokine-mediated signaling pathway GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0071346 cellular response to interferon-gamma GO:0071347 cellular response to interleukin-1 GO:0071353 cellular response to interleukin-4 GO:0071356 cellular response to tumor necrosis factor GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071636 positive regulation of transforming growth factor beta production GO:0071663 positive regulation of granzyme B production GO:0090023 positive regulation of neutrophil chemotaxis GO:2000412 positive regulation of thymocyte migration GO:2000503 positive regulation of natural killer cell chemotaxis GO:2000513 positive regulation of granzyme A production GO:2000518 negative regulation of T-helper 1 cell activation GO:2000538 positive regulation of B cell chemotaxis GO:2000553 positive regulation of T-helper 2 cell cytokine production GO:2000556 positive regulation of T-helper 1 cell cytokine production GO:2000558 positive regulation of immunoglobulin production in mucosal tissue GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
