Description: Homo sapiens zinc finger protein 304 (ZNF304), mRNA. RefSeq Summary (NM_020657): This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein functions as a transcriptional repressor that recruits a corepressor complex to stimulate promoter hypermethylation and transcriptional silencing of target genes. Expression of this gene is upregulated in colorectal, ovarian and breast cancer, and this gene may promote cancer cell survival, growth and invasion. [provided by RefSeq, Jul 2016]. Transcript (Including UTRs) Position: hg19 chr19:57,862,645-57,871,265 Size: 8,621 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr19:57,863,033-57,869,217 Size: 6,185 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HCX3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0005515 protein binding GO:0046872 metal ion binding GO:1990841 promoter-specific chromatin binding
Biological Process: GO:0001525 angiogenesis GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007229 integrin-mediated signaling pathway GO:0007265 Ras protein signal transduction GO:0030335 positive regulation of cell migration GO:0035562 negative regulation of chromatin binding GO:0045766 positive regulation of angiogenesis GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050679 positive regulation of epithelial cell proliferation GO:0090309 positive regulation of methylation-dependent chromatin silencing GO:1900114 positive regulation of histone H3-K9 trimethylation GO:1902466 positive regulation of histone H3-K27 trimethylation GO:2000811 negative regulation of anoikis