Human Gene LMO4 (ENST00000370544.10) from GENCODE V44
Description: Homo sapiens LIM domain only 4 (LMO4), transcript variant 1, mRNA. (from RefSeq NM_006769) RefSeq Summary (NM_006769): This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The encoded protein may play a role as a transcriptional regulator or as an oncogene. [provided by RefSeq, Aug 2008]. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000370544.10 Gencode Gene: ENSG00000143013.13 Transcript (Including UTRs) Position: hg38 chr1:87,328,880-87,348,923 Size: 20,044 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr1:87,332,016-87,344,796 Size: 12,781 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P61968
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001158 enhancer sequence-specific DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0008134 transcription factor binding GO:0046872 metal ion binding
Biological Process: GO:0001843 neural tube closure GO:0003281 ventricular septum development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0021514 ventral spinal cord interneuron differentiation GO:0021522 spinal cord motor neuron differentiation GO:0021527 spinal cord association neuron differentiation GO:0030334 regulation of cell migration GO:0031333 negative regulation of protein complex assembly GO:0033674 positive regulation of kinase activity GO:0042659 regulation of cell fate specification GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048538 thymus development GO:0050865 regulation of cell activation
Cellular Component: GO:0005667 transcription factor complex GO:0031252 cell leading edge
Descriptions from all associated GenBank mRNAs
U24576 - Homo sapiens breast tumor autoantigen (LMO4) mRNA, complete cds. AK292578 - Homo sapiens cDNA FLJ77516 complete cds, highly similar to Homo sapiens LIM domain only 4 (LMO4), mRNA. JD407117 - Sequence 388141 from Patent EP1572962. BC017673 - Homo sapiens LIM domain only 4, mRNA (cDNA clone MGC:17816 IMAGE:3893112), complete cds. JD339220 - Sequence 320244 from Patent EP1572962. JD059307 - Sequence 40331 from Patent EP1572962. JD368585 - Sequence 349609 from Patent EP1572962. BC003600 - Homo sapiens LIM domain only 4, mRNA (cDNA clone MGC:872 IMAGE:3355972), complete cds. JD166932 - Sequence 147956 from Patent EP1572962. JD190284 - Sequence 171308 from Patent EP1572962. AY321514 - Homo sapiens LIM-only 4 protein mRNA, 5' UTR and partial cds. BC065818 - Homo sapiens LIM domain only 4, mRNA (cDNA clone MGC:75040 IMAGE:6196307), complete cds. DQ891447 - Synthetic construct clone IMAGE:100004077; FLH177033.01X; RZPDo839C04124D LIM domain only 4 (LMO4) gene, encodes complete protein. DQ894626 - Synthetic construct Homo sapiens clone IMAGE:100009086; FLH177030.01L; RZPDo839C04123D LIM domain only 4 (LMO4) gene, encodes complete protein. AB384751 - Synthetic construct DNA, clone: pF1KB3107, Homo sapiens LMO4 gene for LIM domain transcription factor LMO4, complete cds, without stop codon, in Flexi system. KJ897865 - Synthetic construct Homo sapiens clone ccsbBroadEn_07259 LMO4 gene, encodes complete protein. JD238789 - Sequence 219813 from Patent EP1572962. JD283829 - Sequence 264853 from Patent EP1572962. JD371466 - Sequence 352490 from Patent EP1572962. JD251572 - Sequence 232596 from Patent EP1572962. JD177886 - Sequence 158910 from Patent EP1572962. JD181720 - Sequence 162744 from Patent EP1572962. JD502777 - Sequence 483801 from Patent EP1572962. JD554775 - Sequence 535799 from Patent EP1572962.