Human Gene SORCS3 (ENST00000369701.8) from GENCODE V44
Description: Homo sapiens sortilin related VPS10 domain containing receptor 3 (SORCS3), mRNA. (from RefSeq NM_014978) RefSeq Summary (NM_014978): This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing. [provided by RefSeq, Dec 2014]. Gencode Transcript: ENST00000369701.8 Gencode Gene: ENSG00000156395.14 Transcript (Including UTRs) Position: hg38 chr10:104,641,290-105,265,242 Size: 623,953 Total Exon Count: 27 Strand: + Coding Region Position: hg38 chr10:104,641,328-105,263,374 Size: 622,047 Coding Exon Count: 27
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UPU3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Sequence and Links to Tools and Databases 
Microarray Expression Data 
