Human Gene CLEC4D (ENST00000299665.3) from GENCODE V44
Description: Homo sapiens C-type lectin domain family 4 member D (CLEC4D), mRNA. (from RefSeq NM_080387) RefSeq Summary (NM_080387): This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000299665.3 Gencode Gene: ENSG00000166527.8 Transcript (Including UTRs) Position: hg38 chr12:8,513,503-8,522,366 Size: 8,864 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr12:8,513,733-8,521,271 Size: 7,539 Coding Exon Count: 6
ID:CLC4D_HUMAN DESCRIPTION: RecName: Full=C-type lectin domain family 4 member D; AltName: Full=C-type lectin superfamily member 8; AltName: Full=C-type lectin-like receptor 6; Short=CLEC-6; FUNCTION: Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells. SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Probable). TISSUE SPECIFICITY: Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma. INDUCTION: By autocrine inflammatory stimuli. SIMILARITY: Contains 1 C-type lectin domain. WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=MCL; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_365";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WXI8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Microarray Expression Data 
