Human Gene ZDHHC20 (ENST00000382466.7) from GENCODE V44
  Description: Homo sapiens zinc finger DHHC-type palmitoyltransferase 20 (ZDHHC20), transcript variant 1, mRNA. (from RefSeq NM_153251)
Gencode Transcript: ENST00000382466.7
Gencode Gene: ENSG00000180776.17
Transcript (Including UTRs)
   Position: hg38 chr13:21,372,573-21,459,369 Size: 86,797 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg38 chr13:21,376,648-21,459,171 Size: 82,524 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:21,372,573-21,459,369)mRNA (may differ from genome)Protein (354 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZDH20_HUMAN
DESCRIPTION: RecName: Full=Probable palmitoyltransferase ZDHHC20; EC=2.3.1.-; AltName: Full=Zinc finger DHHC domain-containing protein 20; Short=DHHC-20;
CATALYTIC ACTIVITY: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
DOMAIN: The DHHC domain is required for palmitoyltransferase activity (By similarity).
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
SIMILARITY: Contains 1 DHHC-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.87 RPKM in Testis
Total median expression: 207.89 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -113.60198-0.574 Picture PostScript Text
3' UTR -1180.304075-0.290 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001594 - Znf_DHHC_palmitoyltrfase

Pfam Domains:
PF01529 - DHHC palmitoyltransferase

ModBase Predicted Comparative 3D Structure on Q5W0Z9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008270 zinc ion binding
GO:0016409 palmitoyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0019706 protein-cysteine S-palmitoyltransferase activity
GO:0046872 metal ion binding

Biological Process:
GO:0018230 peptidyl-L-cysteine S-palmitoylation
GO:0018345 protein palmitoylation

Cellular Component:
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC034944 - Homo sapiens zinc finger, DHHC-type containing 20, mRNA (cDNA clone IMAGE:4824131), complete cds.
BC036691 - Homo sapiens zinc finger, DHHC-type containing 20, mRNA (cDNA clone IMAGE:5261439).
BC037336 - Homo sapiens zinc finger, DHHC-type containing 20, mRNA (cDNA clone IMAGE:5264921).
AL833626 - Homo sapiens mRNA; cDNA DKFZp686M1273 (from clone DKFZp686M1273).
AK090979 - Homo sapiens cDNA FLJ33660 fis, clone BRAMY2026395.
AK098818 - Homo sapiens cDNA FLJ25952 fis, clone SYN00911.
JD091755 - Sequence 72779 from Patent EP1572962.
JD052981 - Sequence 34005 from Patent EP1572962.
JD146265 - Sequence 127289 from Patent EP1572962.
JD323745 - Sequence 304769 from Patent EP1572962.
JD186648 - Sequence 167672 from Patent EP1572962.
JD239334 - Sequence 220358 from Patent EP1572962.
JD313041 - Sequence 294065 from Patent EP1572962.
JD236661 - Sequence 217685 from Patent EP1572962.
JD084723 - Sequence 65747 from Patent EP1572962.
JD565015 - Sequence 546039 from Patent EP1572962.
JD190252 - Sequence 171276 from Patent EP1572962.
JD093381 - Sequence 74405 from Patent EP1572962.
JD553650 - Sequence 534674 from Patent EP1572962.
JD089243 - Sequence 70267 from Patent EP1572962.
JD553138 - Sequence 534162 from Patent EP1572962.
JD135372 - Sequence 116396 from Patent EP1572962.
JD082618 - Sequence 63642 from Patent EP1572962.
JD534839 - Sequence 515863 from Patent EP1572962.
JD155900 - Sequence 136924 from Patent EP1572962.
JD059736 - Sequence 40760 from Patent EP1572962.
JD388370 - Sequence 369394 from Patent EP1572962.
JD321139 - Sequence 302163 from Patent EP1572962.
JD439459 - Sequence 420483 from Patent EP1572962.
JD264315 - Sequence 245339 from Patent EP1572962.
JD557958 - Sequence 538982 from Patent EP1572962.
JD430740 - Sequence 411764 from Patent EP1572962.
JD326871 - Sequence 307895 from Patent EP1572962.
JD101550 - Sequence 82574 from Patent EP1572962.
JD136077 - Sequence 117101 from Patent EP1572962.
JD072329 - Sequence 53353 from Patent EP1572962.
JD225364 - Sequence 206388 from Patent EP1572962.
JD506067 - Sequence 487091 from Patent EP1572962.
JD345681 - Sequence 326705 from Patent EP1572962.
JD388563 - Sequence 369587 from Patent EP1572962.
JD388562 - Sequence 369586 from Patent EP1572962.
AX721051 - Sequence 11 from Patent WO0220754.
JD449058 - Sequence 430082 from Patent EP1572962.
AK295804 - Homo sapiens cDNA FLJ52605 complete cds, highly similar to Probable palmitoyltransferase ZDHHC20 (EC 2.3.1.-).
BC050367 - Homo sapiens zinc finger, DHHC-type containing 20, mRNA (cDNA clone MGC:51816 IMAGE:5591379), complete cds.
BC067898 - Homo sapiens zinc finger, DHHC-type containing 20, mRNA (cDNA clone IMAGE:5297959), complete cds.
BC110517 - Homo sapiens zinc finger, DHHC-type containing 20, mRNA (cDNA clone MGC:126005 IMAGE:40032074), complete cds.
AK299354 - Homo sapiens cDNA FLJ60835 complete cds, highly similar to Probable palmitoyltransferase ZDHHC20 (EC 2.3.1.-).
KJ904060 - Synthetic construct Homo sapiens clone ccsbBroadEn_13454 ZDHHC20 gene, encodes complete protein.
KJ906464 - Synthetic construct Homo sapiens clone ccsbBroadEn_16134 ZDHHC20 gene, encodes complete protein.
CU686599 - Synthetic construct Homo sapiens gateway clone IMAGE:100022947 5' read ZDHHC20 mRNA.
AX794780 - Sequence 7 from Patent WO03052093.

-  Other Names for This Gene
  Alternate Gene Symbols: A8MTV9, C9JG20, ENST00000382466.1, ENST00000382466.2, ENST00000382466.3, ENST00000382466.4, ENST00000382466.5, ENST00000382466.6, NM_153251, Q5W0Z9, Q6NVU8, uc001uoa.1, uc001uoa.2, uc001uoa.3, uc001uoa.4, ZDH20_HUMAN
UCSC ID: ENST00000382466.7
RefSeq Accession: NM_153251
Protein: Q5W0Z9 (aka ZDH20_HUMAN)
CCDS: CCDS81758.1, CCDS45017.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.