Human Gene ONECUT1 (ENST00000305901.7) from GENCODE V44
Description: Homo sapiens one cut homeobox 1 (ONECUT1), transcript variant 1, mRNA. (from RefSeq NM_004498) RefSeq Summary (NM_004498): This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. Gencode Transcript: ENST00000305901.7 Gencode Gene: ENSG00000169856.9 Transcript (Including UTRs) Position: hg38 chr15:52,755,053-52,790,336 Size: 35,284 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr15:52,757,555-52,789,884 Size: 32,330 Coding Exon Count: 2
ID:HNF6_HUMAN DESCRIPTION: RecName: Full=Hepatocyte nuclear factor 6; Short=HNF-6; AltName: Full=One cut domain family member 1; AltName: Full=One cut homeobox 1; FUNCTION: Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. SUBUNIT: Binds DNA as a monomer (By similarity). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Highly expressed in liver; lower expression in testis and skin. SIMILARITY: Belongs to the CUT homeobox family. SIMILARITY: Contains 1 CUT DNA-binding domain. SIMILARITY: Contains 1 homeobox DNA-binding domain. WEB RESOURCE: Name=Wikipedia; Note=Hepatocyte nuclear factors entry; URL="http://en.wikipedia.org/wiki/Hepatocyte_nuclear_factors";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UBC0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding
Biological Process: GO:0001889 liver development GO:0001952 regulation of cell-matrix adhesion GO:0002064 epithelial cell development GO:0006006 glucose metabolic process GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0007219 Notch signaling pathway GO:0007492 endoderm development GO:0009653 anatomical structure morphogenesis GO:0030154 cell differentiation GO:0030183 B cell differentiation GO:0030335 positive regulation of cell migration GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway GO:0031016 pancreas development GO:0031018 endocrine pancreas development GO:0045165 cell fate commitment GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048536 spleen development GO:0048731 system development GO:0060271 cilium assembly
U77975 - Homo sapiens hepatocyte nuclear factor 6 (HNF-6) mRNA, partial cds. U96173 - Human hepatocyte nuclear factor-6 alpha (HNF6) mRNA, complete cds. JD289557 - Sequence 270581 from Patent EP1572962. JD404439 - Sequence 385463 from Patent EP1572962. BC140830 - Homo sapiens one cut homeobox 1, mRNA (cDNA clone MGC:176507 IMAGE:9021698), complete cds. JD201739 - Sequence 182763 from Patent EP1572962. JD512194 - Sequence 493218 from Patent EP1572962. JD563761 - Sequence 544785 from Patent EP1572962. JD453728 - Sequence 434752 from Patent EP1572962. EU532019 - Homo sapiens clone IMAGE: 4372264 one cut homeobox 1 (ONECUT1) mRNA, partial cds. JD037227 - Sequence 18251 from Patent EP1572962. JD240523 - Sequence 221547 from Patent EP1572962. JD110872 - Sequence 91896 from Patent EP1572962. KJ891370 - Synthetic construct Homo sapiens clone ccsbBroadEn_00764 ONECUT1 gene, encodes complete protein. AB463985 - Synthetic construct DNA, clone: pF1KB9730, Homo sapiens ONECUT1 gene for one cut homeobox 1, without stop codon, in Flexi system. JD129282 - Sequence 110306 from Patent EP1572962. JD191494 - Sequence 172518 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04950 - Maturity onset diabetes of the young
Reactome (by CSHL, EBI, and GO)
Protein Q9UBC0 (Reactome details) participates in the following event(s):
R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells R-HSA-186712 Regulation of beta-cell development R-HSA-1266738 Developmental Biology
US Server
Sequence and Links to Tools and Databases 
Microarray Expression Data 
