Human Gene ICAM5 (ENST00000221980.5) from GENCODE V44
Description: Homo sapiens intercellular adhesion molecule 5 (ICAM5), mRNA. (from RefSeq NM_003259) RefSeq Summary (NM_003259): The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000221980.5 Gencode Gene: ENSG00000105376.5 Transcript (Including UTRs) Position: hg38 chr19:10,289,952-10,296,778 Size: 6,827 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr19:10,290,044-10,296,616 Size: 6,573 Coding Exon Count: 11
ID:ICAM5_HUMAN DESCRIPTION: RecName: Full=Intercellular adhesion molecule 5; Short=ICAM-5; AltName: Full=Telencephalin; Flags: Precursor; FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon. PTM: Glycosylation at Asn-54 is critical for functional folding (By similarity). SIMILARITY: Belongs to the immunoglobulin superfamily. ICAM family. SIMILARITY: Contains 9 Ig-like C2-type (immunoglobulin-like) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UMF0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Sequence and Links to Tools and Databases 
Microarray Expression Data 
