Human Gene RAD23A (ENST00000586534.6) from GENCODE V44
Description: Homo sapiens RAD23 homolog A, nucleotide excision repair protein (RAD23A), transcript variant 1, mRNA. (from RefSeq NM_005053) RefSeq Summary (NM_005053): The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]. Gencode Transcript: ENST00000586534.6 Gencode Gene: ENSG00000179262.10 Transcript (Including UTRs) Position: hg38 chr19:12,945,862-12,953,642 Size: 7,781 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr19:12,945,949-12,953,049 Size: 7,101 Coding Exon Count: 9
ID:RD23A_HUMAN DESCRIPTION: RecName: Full=UV excision repair protein RAD23 homolog A; Short=HR23A; Short=hHR23A; FUNCTION: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC. FUNCTION: Involved in vpr-dependent replication of HIV-1 in non- proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome. SUBUNIT: Interacts with XPC; the interaction is suggesting the existence of a functional equivalent variant XPC complex. Interacts with PSMD4 and PSMC5. Interacts with ATXN3. Interacts with HIV-1 vpr. Interacts with UBQLN2. INTERACTION: P55036:PSMD4; NbExp=2; IntAct=EBI-746453, EBI-359318; Q13501:SQSTM1; NbExp=2; IntAct=EBI-746453, EBI-307104; Q9UHD9:UBQLN2; NbExp=3; IntAct=EBI-746453, EBI-947187; SUBCELLULAR LOCATION: Nucleus. DOMAIN: The ubiquitin-like domain mediates interaction with ATXN3. DOMAIN: The ubiquitin-like (UBL) and the UBA (ubiquitin- associated) domains interact intramolecularly in a highly dynamic manner, as each UBA domain competes for an overlapping UBL domain surface. Binding of ubiquitin or proteasome subunit PSMD4 disrupt the UBL-UBA domain interactions and drive RAD23A in to an open conformation. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the RAD23 family. SIMILARITY: Contains 2 UBA domains. SIMILARITY: Contains 1 ubiquitin-like domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/rad23a/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P54725
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006281 DNA repair GO:0006289 nucleotide-excision repair GO:0006974 cellular response to DNA damage stimulus GO:0016032 viral process GO:0016579 protein deubiquitination GO:0031648 protein destabilization GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0045070 positive regulation of viral genome replication GO:0045787 positive regulation of cell cycle
US Server
Sequence and Links to Tools and Databases 
Microarray Expression Data 
