ID:CLPT1_HUMAN DESCRIPTION: RecName: Full=Cleft lip and palate transmembrane protein 1; FUNCTION: May play a role in T-cell development (By similarity). INTERACTION: Q8VCW4:Unc93b1 (xeno); NbExp=2; IntAct=EBI-2873194, EBI-6116986; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: Widely expressed. POLYMORPHISM: A chromosomal translocation involving CLPTM1 is found in a family with cleft lip and palate. However, no etiologic link with the disease is characterized. Translocation t(2;19)(q11.2;q13.3). SIMILARITY: Belongs to the CLPTM1 family. SEQUENCE CAUTION: Sequence=AAH04865.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=AAP35926.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05602 - Cleft lip and palate transmembrane protein 1 (CLPTM1)
ModBase Predicted Comparative 3D Structure on O96005
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007275 multicellular organism development GO:0030154 cell differentiation GO:0033081 regulation of T cell differentiation in thymus
Cellular Component: GO:0005887 integral component of plasma membrane GO:0009897 external side of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane
Descriptions from all associated GenBank mRNAs
AK310826 - Homo sapiens cDNA, FLJ17868. AK316094 - Homo sapiens cDNA, FLJ78993 complete cds, highly similar to Cleft lip and palate transmembrane protein 1. AK293314 - Homo sapiens cDNA FLJ59465 complete cds, highly similar to Cleft lip and palate transmembrane protein 1. AK304480 - Homo sapiens cDNA FLJ58081 complete cds, highly similar to Cleft lip and palate transmembrane protein 1. LF384224 - JP 2014500723-A/191727: Polycomb-Associated Non-Coding RNAs. MA619801 - JP 2018138019-A/191727: Polycomb-Associated Non-Coding RNAs. BC004865 - Homo sapiens cleft lip and palate associated transmembrane protein 1, mRNA (cDNA clone MGC:10593 IMAGE:3840991), complete cds. AK223553 - Homo sapiens mRNA for cleft lip and palate associated transmembrane protein 1 variant, clone: FCC126F08. AK074935 - Homo sapiens cDNA FLJ90454 fis, clone NT2RP3001560, highly similar to Cleft lip and palate transmembrane protein 1. AK075262 - Homo sapiens cDNA FLJ90781 fis, clone THYRO1001242, highly similar to Homo sapiens cleft lip and palate transmembrane protein 1 (CLPTM1) mRNA. AF037339 - Homo sapiens cleft lip and palate transmembrane protein 1 (CLPTM1) mRNA, complete cds. BC012359 - Homo sapiens cleft lip and palate associated transmembrane protein 1, mRNA (cDNA clone MGC:20444 IMAGE:4685026), complete cds. CU680306 - Synthetic construct Homo sapiens gateway clone IMAGE:100017445 5' read CLPTM1 mRNA. DQ895436 - Synthetic construct Homo sapiens clone IMAGE:100009896; FLH184387.01L; RZPDo839F05143D cleft lip and palate associated transmembrane protein 1 (CLPTM1) gene, encodes complete protein. KJ905716 - Synthetic construct Homo sapiens clone ccsbBroadEn_15386 CLPTM1 gene, encodes complete protein. DQ892236 - Synthetic construct clone IMAGE:100004866; FLH184391.01X; RZPDo839F05144D cleft lip and palate associated transmembrane protein 1 (CLPTM1) gene, encodes complete protein. KU177986 - Homo sapiens cleft lip and palate associated transmembrane protein 1 isoform 1 (CLPTM1) mRNA, partial cds, alternatively spliced. KU177987 - Homo sapiens cleft lip and palate associated transmembrane protein 1 isoform 2 (CLPTM1) mRNA, complete cds. BT007262 - Homo sapiens cleft lip and palate associated transmembrane protein 1 mRNA, complete cds. KJ896619 - Synthetic construct Homo sapiens clone ccsbBroadEn_06013 CLPTM1 gene, encodes complete protein. JD436564 - Sequence 417588 from Patent EP1572962. LF367000 - JP 2014500723-A/174503: Polycomb-Associated Non-Coding RNAs. MA602577 - JP 2018138019-A/174503: Polycomb-Associated Non-Coding RNAs. LF366997 - JP 2014500723-A/174500: Polycomb-Associated Non-Coding RNAs. MA602574 - JP 2018138019-A/174500: Polycomb-Associated Non-Coding RNAs. LF366996 - JP 2014500723-A/174499: Polycomb-Associated Non-Coding RNAs. MA602573 - JP 2018138019-A/174499: Polycomb-Associated Non-Coding RNAs. LF366994 - JP 2014500723-A/174497: Polycomb-Associated Non-Coding RNAs. MA602571 - JP 2018138019-A/174497: Polycomb-Associated Non-Coding RNAs. LF366989 - JP 2014500723-A/174492: Polycomb-Associated Non-Coding RNAs. MA602566 - JP 2018138019-A/174492: Polycomb-Associated Non-Coding RNAs. LF366988 - JP 2014500723-A/174491: Polycomb-Associated Non-Coding RNAs. MA602565 - JP 2018138019-A/174491: Polycomb-Associated Non-Coding RNAs. LF366987 - JP 2014500723-A/174490: Polycomb-Associated Non-Coding RNAs. MA602564 - JP 2018138019-A/174490: Polycomb-Associated Non-Coding RNAs. AK027698 - Homo sapiens cDNA FLJ14792 fis, clone NT2RP4001149, highly similar to Homo sapiens cleft lip and palate transmembrane protein 1 (CLPTM1) mRNA. LF366984 - JP 2014500723-A/174487: Polycomb-Associated Non-Coding RNAs. MA602561 - JP 2018138019-A/174487: Polycomb-Associated Non-Coding RNAs. LF366983 - JP 2014500723-A/174486: Polycomb-Associated Non-Coding RNAs. MA602560 - JP 2018138019-A/174486: Polycomb-Associated Non-Coding RNAs. JD142248 - Sequence 123272 from Patent EP1572962. JD391955 - Sequence 372979 from Patent EP1572962. JD484758 - Sequence 465782 from Patent EP1572962. JD496689 - Sequence 477713 from Patent EP1572962. JD161317 - Sequence 142341 from Patent EP1572962. JD085229 - Sequence 66253 from Patent EP1572962. JD437122 - Sequence 418146 from Patent EP1572962. JD446029 - Sequence 427053 from Patent EP1572962. JD390286 - Sequence 371310 from Patent EP1572962. JD056225 - Sequence 37249 from Patent EP1572962.